DHB1 Rabbit pAb
-YN0705
主要信息
Target
DHB1
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, ELISA
MW
36kD (Observed)
Conjugate/Modification
Unmodified
货号: YN0705
规格
价格
货期
数量
200μL
￥3,780.00
现货
0
100μL
￥2,300.00
现货
0
40μL
￥960.00
现货
0
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已收藏
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详细信息
推荐稀释比
WB 1:500-2000; ELISA 1:5000-20000
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
DHB1 Polyclonal Antibody detects endogenous levels of protein.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year (Do not lower than -25°C)
浓度
1 mg/ml
实测条带
36kD
修饰
Unmodified
克隆性
Polyclonal
同种型
IgG
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抗原&靶点信息
免疫原:
Synthesized peptide derived from part region of human protein. AA range:62-162
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特异性:
DHB1 Polyclonal Antibody detects endogenous levels of protein.
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基因名称:
HSD17B1 E17KSR EDH17B1 EDH17B2 EDHB17
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蛋白名称:
Estradiol 17-beta-dehydrogenase 1 (17-beta-hydroxysteroid dehydrogenase type 1) (17-beta-HSD 1) (20 alpha-hydroxysteroid dehydrogenase) (20-alpha-HSD) (E2DH) (Placental 17-beta-hydroxysteroid dehydrogenase)
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背景:
hydroxysteroid 17-beta dehydrogenase 1 (HSD17B1) Homo sapiens This gene encodes a member of the 17beta-hydroxysteroid dehydrogenase family of short-chain dehydrogenases/reductases. It has a dual function in estrogen activation and androgen inactivation and plays a major role in establishing the estrogen E2 concentration gradient between serum and peripheral tissues. The encoded protein catalyzes the last step in estrogen activation , using NADPH to convert estrogens E1 and E2 and androgens like 4-androstenedione , to testosterone. It has an N-terminal short-chain dehydrogenase domain with a cofactor binding site , and a narrow , hydrophobic C-terminal domain with a steroid substrate binding site. This gene is expressed primarily in the placenta and ovarian granulosa cells , and to a lesser extent , in the endometrium , adipose tissue , and prostate. Polymorphisms in this gene have been linked to breast and prostate cancer. A pseudogene of this gene has
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功能:
Catalytic activity:Estradiol-17-beta + NAD (P) (+) = estrone + NAD (P) H. ,Function:Favors the reduction of estrogens and androgens. Also has 20-alpha-HSD activity. Uses preferentially NADH. ,online information:The Singapore human mutation and polymorphism database ,pathway:Steroid biosynthesis; estrogen biosynthesis. ,similarity:Belongs to the short-chain dehydrogenases/reductases (SDR) family. ,subunit:Homodimer. ,
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细胞定位:
Cytoplasm.
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组织表达:
研究领域:
>>Steroid hormone biosynthesis ;
>>Metabolic pathways ;
>>Ovarian steroidogenesis
>>Metabolic pathways ;
>>Ovarian steroidogenesis
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文献引用（{{totalcount}}）
货号: YN0705
规格
价格
货期
数量
200μL
￥3,780.00
现货
0
100μL
￥2,300.00
现货
0
40μL
￥960.00
现货
0
加入购物车
已收藏
收藏
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