CDT1 Rabbit pAb
-YN0650
主要信息
Target
CDT1
Host Species
Rabbit
Reactivity
Human, Mouse
Applications
WB, ELISA
MW
60kD (Observed)
Conjugate/Modification
Unmodified
货号: YN0650
规格
价格
货期
数量
200μL
￥3,780.00
现货
0
100μL
￥2,300.00
现货
0
40μL
￥960.00
现货
0
加入购物车
已收藏
收藏
详细信息
推荐稀释比
WB 1:500-2000; ELISA 1:5000-20000
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
CDT1 Polyclonal Antibody detects endogenous levels of protein.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year (Do not lower than -25°C)
浓度
1 mg/ml
实测条带
60kD
修饰
Unmodified
克隆性
Polyclonal
同种型
IgG
相关产品
Secondary Antibodies
Goat Anti Mouse IgG(H+L) (HRP)
RS0001
预览→
Secondary Antibodies
Goat Anti Rabbit IgG(H+L) (HRP)
RS0002
预览→
Primary Antibodies
β-actin (PTR2364) Mouse mAb
YM3028
预览→
Primary Antibodies
GAPDH (PTR2304) Mouse mAb
YM3029
预览→
抗原&靶点信息
免疫原:
Synthesized peptide derived from part region of human protein. AA range:141-191
展开内容
特异性:
CDT1 Polyclonal Antibody detects endogenous levels of protein.
展开内容
基因名称:
CDT1
展开内容
蛋白名称:
DNA replication factor Cdt1 (Double parked homolog) (DUP)
展开内容
背景:
The protein encoded by this gene is involved in the formation of the pre-replication complex that is necessary for DNA replication. The encoded protein can bind geminin , which prevents replication and may function to prevent this protein from initiating replication at inappropriate origins. Phosphorylation of this protein by cyclin A-dependent kinases results in degradation of the protein. [provided by RefSeq , Mar 2011] ,
展开内容
功能:
developmental stage:Present during G1 and early S phase of the cell cycle. Degraded during the late S , G2 , and M phases. ,Function:Cooperates with CDC6 to promote the loading of the mini-chromosome maintenance complex onto chromatin to form the pre-replication complex necessary to initiate DNA replication. Binds DNA in a sequence- , strand- , and conformation-independent manner. Potential oncogene. ,PTM:Phosphorylated by cyclin A-dependent kinases which results in the binding of CDT1 to the F-box protein SKP2 and subsequent degradation. Binding to GMNN is not affected by phosphorylation. ,PTM:Ubiquitinated , leading to its subsequent degradation. The interaction with GMNN protects it against ubiquitination. ,similarity:Belongs to the Cdt1 family. ,subunit:Interaction with GMNN inhibits both binding of the MCM complex to origins of replication and DNA-binding activity. ,
展开内容
细胞定位:
Nucleus . Chromosome , centromere , kinetochore . Transiently localizes to kinetochores during prometaphase and metaphase. .
展开内容
文献引用（{{totalcount}}）
货号: YN0650
规格
价格
货期
数量
200μL
￥3,780.00
现货
0
100μL
￥2,300.00
现货
0
40μL
￥960.00
现货
0
加入购物车
已收藏
收藏
Recently Viewed Products
Clear all
×
Toggle night Mode
{{pinfoXq.title || ''}}
Catalog: {{pinfoXq.catalog || ''}}
Filter：
All
{{item.name}}
{{pinfo.title}}
-{{pinfo.catalog}}
主要信息
Target
{{pinfo.target}}
Reactivity
{{pinfo.react}}
Applications
{{pinfo.applicat}}
Conjugate/Modification
{{pinfo.coupling}}/{{pinfo.modific}}
MW (kDa)
{{pinfo.mwcalc}}
Host Species
{{pinfo.hostspec}}
Isotype
{{pinfo.isotype}}
产品 {{index}}/{{pcount}}
上一个产品
下一个产品
{{pvTitle}}
滚轮缩放图片
{{pvDescr}}