Synthesized peptide derived from human protein . at AA range: 710-790

AMOT Polyclonal Antibody detects endogenous levels of protein.

AMOT KIAA1071

Angiomotin

This gene belongs to the motin family of angiostatin binding proteins characterized by conserved coiled-coil domains and C-terminal PDZ binding motifs. The encoded protein is expressed predominantly in endothelial cells of capillaries as well as larger vessels of the placenta where it may mediate the inhibitory effect of angiostatin on tube formation and the migration of endothelial cells toward growth factors during the formation of new blood vessels. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq , Jul 2008] ,

Domain:The angiostatin binding domain (871-1005) allows the binding to angiostatin. ,Domain:The coiled coil domain interacts directly with the BAR domain of ARHGAP17. ,Function:Plays a central role in tight junction maintenance via the complex formed with ARHGAP17 , which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions. ,miscellaneous:'Motus' means motility in Latin. ,PTM:Phosphorylated upon DNA damage , probably by ATM or ATR. ,sequence Caution:Contaminating sequence. Potential poly-A sequence. ,similarity:Belongs to the angiomotin family. ,subcellular location:Localized on the cell surface. May act as a transmembrane protein. ,subunit:Component of a complex whose core is composed of ARHGAP17 , AMOT , MPP5/PALS1 , INADL/PATJ and PARD3/PAR3. Interacts with MAGI1. Isoform 1 interacts with angiostatin. ,tissue specificity:Expressed in placenta and skeletal muscle. Found in the endothelial cells of capillaries as well as larger vessels of the placenta. ,

Cell junction , tight junction . Localized on the cell surface. May act as a transmembrane protein.

>>Hippo signaling pathway ;
>>Tight junction