SLUG (PT0536R) PT™ Rabbit mAb

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实验Protocols

Western Blot IHC IF/ICC IP

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-YM8357

文献引用（1）

说明书

SDS

FAQ

主要信息

Target

SLUG

Host Species

Rabbit

Reactivity

Human, Mouse

Applications

WB, IF, IP, ELISA

30kD (Calculated)

36kD (Observed)

Conjugate/Modification

Unmodified

All {{item.name}}

货号: YM8357

规格

价格

货期

数量

200μL

￥3,780.00

现货

100μL

￥2,300.00

现货

40μL

￥960.00

现货

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详细信息相关产品抗原&靶点信息信号通路文献引用(1)

详细信息

推荐稀释比

WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200;

组成

PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

特异性

Endogenous

纯化工艺

Protein A

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

理论分子量

30kD

实测条带

36kD

修饰

Unmodified

克隆性

Monoclonal

克隆号

PT0536R

同种型

IgG,Kappa

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Goat Anti Mouse IgG(H+L) (HRP)

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Secondary Antibodies

Goat Anti Rabbit IgG(H+L) (HRP)

RS0002

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Primary Antibodies

β-actin (PTR2364) Mouse mAb

YM3028

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抗原&靶点信息

特异性:

Endogenous

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基因名称:

SNAI2 SLUG SLUGH

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蛋白名称:

Zinc finger protein SNAI2

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别名:

SNAI2 ;
SLUG ;
SLUGH ;
Zinc finger protein SNAI2 ;
Neural crest transcription factor Slug ;
Protein snail homolog 2

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数据库链接:

Organism	基因 ID	SwissProt
Human	6591;	O43623;
Mouse	20583;	P97469;

背景:

Snail family transcriptional repressor 2(SNAI2) Homo sapiens This gene encodes a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. Mutations in this gene may be associated with sporatic cases of neural tube defects. [provided by RefSeq, Jul 2008],

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功能:

Disease:Defects in SNAI2 are a cause of neural tube defects (NTD).,disease:Defects in SNAI2 are the cause of Waardenburg syndrome type 2D (WS2D) [MIM:608890]. WS2 is a genetically heterogeneous, autosomal dominant disorder characterized by sensorineural deafness, pigmentary disturbances, and absence of dystopia canthorum. The frequency of deafness is higher in WS2 than in WS1.,Function:Transcriptional repressor. Involved in the generation and migration of neural crest cells.,similarity:Belongs to the snail C2H2-type zinc-finger protein family.,similarity:Contains 5 C2H2-type zinc fingers.,tissue specificity:Expressed in placenta and adult heart, pancreas, liver, kidney and skeletal muscle.,

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细胞定位:

Cytoplasm, Nucleus

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组织表达:

Expressed in most adult human tissues, including spleen, thymus, prostate, testis, ovary, small intestine, colon, heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Not detected in peripheral blood leukocyte. Expressed in the dermis and in all layers of the epidermis, with high levels of expression in the basal layers (at protein level). Expressed in osteoblasts (at protein level). Expressed in mesenchymal stem cells (at protein level). Expressed in breast tumor cells (at protein level).

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研究领域:

>>Hippo signaling pathway ;
>>Adherens junction

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信号通路

Cellular Processes >> Cellular community - eukaryotes >> Adherens junction Environmental Information Processing >> Signal transduction >> Hippo signaling pathway