HDAC6 (ABT-HDAC6) Mouse mAb
-YM6120
主要信息
Target
HDAC6
Host Species
Mouse
Reactivity
Human, Mouse
Applications
IHC, ELISA
Conjugate/Modification
Unmodified
货号: YM6120
规格
价格
货期
数量
200μL
￥3,780.00
现货
0
100μL
￥2,300.00
现货
0
40μL
￥960.00
现货
0
加入购物车
已收藏
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详细信息
推荐稀释比
IHC 1:200-400; ELISA 1:500-5000
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
特异性
The antibody can specifically recognize human HDAC6 protein.
纯化工艺
The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.
储存
-15°C to -25°C/1 year (Do not lower than -25°C)
修饰
Unmodified
克隆性
Monoclonal
克隆号
ABT-HDAC6
同种型
IgG1, Kappa
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抗原&靶点信息
免疫原:
Synthesized peptide derived from human HDAC6 AA range: 1100-1215
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特异性:
The antibody can specifically recognize human HDAC6 protein.
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基因名称:
HDAC6 KIAA0901 JM21
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蛋白名称:
Histone deacetylase 6 (HD6) (EC 3.5.1.98)
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背景:
Histones play a critical role in transcriptional regulation , cell cycle progression , and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription. [provided by RefSeq , Jul 2008] ,
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功能:
Catalytic activity:Hydrolysis of an N (6) -acetyl-lysine residue of a histone to yield a deacetylated histone. ,Function:Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A , H2B , H3 and H4) . Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation , cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity) . Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin. ,PTM:Sumoylated in vitro. ,PTM:Ubiquitinated. Its polyubiquitination however does not lead to its degradation. ,similarity:Belongs to the histone deacetylase family. Type 2 subfamily. ,similarity:Contains 1 UBP-type zinc finger. ,subcellular location:It is mainly cytoplasmic , where it is associated with microtubules. ,subunit:Interacts with CBFA2T3 , HDAC11 and SIRT2. Interacts with F-actin. Interacts with BBIP10. ,
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细胞定位:
Cytoplasmic
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研究领域:
>>Neutrophil extracellular trap formation ;
>>Amyotrophic lateral sclerosis ;
>>Alcoholism ;
>>Viral carcinogenesis
>>Amyotrophic lateral sclerosis ;
>>Alcoholism ;
>>Viral carcinogenesis
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信号通路
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货号: YM6120
规格
价格
货期
数量
200μL
￥3,780.00
现货
0
100μL
￥2,300.00
现货
0
40μL
￥960.00
现货
0
加入购物车
已收藏
收藏
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