Synthesized peptide derived from human Glial Fibrillary Acidic Protein AA range: 300-432

The antibody can specifically recognize human GFAP protein.

GFAP

wu:fb34h11;ALXDRD;cb345;etID36982.3;FLJ42474;FLJ45472;GFAP;GFAP_HUMAN;gfapl;Glial fibrillary acidic protein;Intermediate filament protein;wu:fk42c12;xx:af506734;zgc:110485

wu:fb34h11 ;
ALXDRD ;
cb345 ;
etID36982.3 ;
FLJ42474 ;
FLJ45472 ;
GFAP ;
GFAP_HUMAN ;
gfapl ;
Glial fibrillary acidic protein ;
Intermediate filament protein ;
wu:fk42c12 ;
xx:af506734 ;
zgc:110485

This gene encodes one of the major intermediate filament proteins of mature astrocytes. It is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease , a rare disorder of astrocytes in the central nervous system. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq , Oct 2008] ,

Alternative products:Isoforms differ in the C-terminal region which is encoded by alternative exons ,Disease:Defects in GFAP are a cause of Alexander disease (ALEXD) [MIM:203450]. Alexander disease is a rare disorder of the central nervous system. It is a progressive leukoencephalopathy whose hallmark is the widespread accumulation of Rosenthal fibers which are cytoplasmic inclusions in astrocytes. The most common form affects infants and young children , and is characterized by progressive failure of central myelination , usually leading to death usually within the first decade. Infants with Alexander disease develop a leukoencephalopathy with macrocephaly , seizures , and psychomotor retardation. Patients with juvenile or adult forms typically experience ataxia , bulbar signs and spasticity , and a more slowly progressive course. ,Function:GFAP , a class-III intermediate filament , is a cell-specific marker that , during the development of the central nervous system , distinguishes astrocytes from other glial cells. ,online information:GFAP entry ,similarity:Belongs to the intermediate filament family. ,subcellular location:Associated with intermediate filaments. ,subunit:Interacts with SYNM (By similarity) . Isoform 3 interacts with PSEN1 (via N-terminus) . ,tissue specificity:Expressed in cells lacking fibronectin. ,

Cytoplasmic

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