EIF4E

Eukaryotic translation initiation factor 4E ;
eIF-4E ;
eIF4E ;
eIF-4F 25 kDa subunit ;
mRNA cap-binding protein ;

caution:Was originally thought to be phosphorylated on Ser-53 (PubMed:3112145) ; this was later shown to be wrong (PubMed:7665584) . ,function:Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. ,PTM:Phosphorylation increases the ability of the protein to bind to mRNA caps and to form the eIF4F complex. ,similarity:Belongs to the eukaryotic initiation factor 4E family. ,subunit:eIF4F is a multi-subunit complex , the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A , EIF4E and EIF4G1/EIF4G3. EIF4E is also known to interact with other partners. The interaction with EIF4ENIF1 mediates the import into the nucleus. Nonphosphorylated EIF4EBP1 , EIF4EBP2 and EIF4EBP3 compete with EIF4G1/EIF4G3 to interact with EIF4E; insulin stimulated MAP-kinase (MAPK1 and MAPK3) phosphorylation of EIF4EBP1 causes dissociation of the complex allowing EIF4G1/EIF4G3 to bind and consequent initiation of translation. Rapamycin can attenuate insulin stimulation , mediated by FKBPs. Interacts mutually exclusive with EIF4A1 and EIF4A2. Interacts with NGDN and PIWIL2 (By similarity) . Interacts with Lassa virus Z protein. ,

translation , translational initiation , regulation of translation , posttranscriptional regulation of gene expression ,regulation of cellular protein metabolic process ,

Cytoplasm , P-body . Cytoplasm . Cytoplasm , Stress granule . Nucleus . Interaction with EIF4ENIF1/4E-T is required for localization to processing bodies (P-bodies) (PubMed:16157702 , PubMed:24335285 , PubMed:25923732) . Imported in the nucleus via interaction with EIF4ENIF1/4E-T via a piggy-back mechanism (PubMed:10856257) . .