Amino acid:35-314,with human FC tag.

CEACAM5

Carcinoembryonic antigen-related cell adhesion molecule 5 (Carcinoembryonic antigen) (CEA) (Meconium antigen 100) (CD antigen CD66e)

Carcinoembryonic antigen-related cell adhesion molecule 5 ;
Carcinoembryonic antigen ;
CEA ;
Meconium antigen 100 ;
CD antigen CD66e ;
CEACAM5 ;
CEA ;

Cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression (PubMed:10864933, PubMed:10910050, PubMed:2803308). Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6 (PubMed:2803308). Plays a role as an oncogene by promoting tumor progression; induces resistance to anoikis of colorectal carcinoma cells (PubMed:10910050).; (Microbial infection) Receptor for E.coli Dr adhesins. Binding of E.coli Dr adhesins leads to dissociation of the homodimer.

Cell membrane ; Lipid-anchor, GPI-anchor . Apical cell membrane . Cell surface . Note=Localized to the apical glycocalyx surface. .

Expressed in columnar epithelial and goblet cells of the colon (at protein level) (PubMed:10436421). Found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon.