Amino acid:19-256,with human FC tag.

ICOSLG

ICOS ligand (B7 homolog 2) (B7-H2) (B7-like protein Gl50) (B7-related protein 1) (B7RP-1) (CD antigen CD275)

ICOS ligand ;
B7 homolog 2 ;
B7-H2 ;
B7-like protein Gl50 ;
B7-related protein 1 ;
B7RP-1 ;
CD antigen CD275 ;
ICOSLG ;
B7H2 ;
B7RP1 ;
ICOSL ;
KIAA0653 ;

Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function (By similarity).

Cell membrane ; Single-pass type I membrane protein .

Isoform 1 is widely expressed (brain, heart, kidney, liver, lung, pancreas, placenta, skeletal muscle, bone marrow, colon, ovary, prostate, testis, lymph nodes, leukocytes, spleen, thymus and tonsil), while isoform 2 is detected only in lymph nodes, leukocytes and spleen. Expressed on activated monocytes and dendritic cells.