CHEK2

Serine/threonine-protein kinase Chk2 ;
CHK2 checkpoint homolog ;
Cds1 homolog ;
Hucds1 ;
hCds1 ;
Checkpoint kinase 2 ;

catalytic activity:ATP + a protein = ADP + a phosphoprotein. ,cofactor:Magnesium. ,disease:Defects in CHEK2 are associated with Li-Fraumeni syndrome 2 (LFS2) [MIM:609265]; a highly penetrant familial cancer phenotype usually associated with inherited mutations in p53/TP53. ,disease:Defects in CHEK2 are found in some patients with osteosarcoma (OSRC) [MIM:259500]. ,disease:Defects in CHEK2 are found in some patients with prostate cancer (CaP) [MIM:176807]. ,enzyme regulation:Rapidly phosphorylated on Thr-68 by MLTK in response to DNA damage and to replication block. Kinase activity is also up-regulated by autophosphorylation. ,function:Regulates cell cycle checkpoints and apoptosis in response to DNA damage , particularly to DNA double-strand breaks. Inhibits CDC25C phosphatase by phosphorylation on 'Ser-216' , preventing the entry into mitosis. May also play a role in meiosis. Regulates the TP53 tumor suppressor through phosphorylation at 'Thr-18' and 'Ser-20'. ,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHK2 subfamily. ,similarity:Contains 1 FHA domain. ,similarity:Contains 1 protein kinase domain. ,subcellular location:Isoform 10 is present throughout the cell. ,tissue specificity:High expression is found in testis , spleen , colon and peripheral blood leukocytes. Low expression is found in other tissues. ,

cell cycle checkpoint , DNA damage checkpoint , protein amino acid phosphorylation , phosphorus metabolic process ,phosphate metabolic process , induction of apoptosis , response to DNA damage stimulus , cell cycle , intracellular signaling cascade , induction of apoptosis by intracellular signals , DNA damage response , signal transduction resulting in induction of apoptosis , regulation of cell death , positive regulation of cell death , induction of programmed cell death ,phosphorylation , DNA integrity checkpoint , cellular response to stress , DNA damage response , signal transduction ,regulation of apoptosis , positive regulation of apoptosis , regulation of programmed cell death , positive regulation of programmed cell death , regulation of cell cycle ,

[Isoform 2]: Nucleus. Isoform 10 is present throughout the cell.; [Isoform 4]: Nucleus.; [Isoform 7]: Nucleus.; [Isoform 9]: Nucleus.; [Isoform 12]: Nucleus.; Nucleus , PML body. Nucleus , nucleoplasm. Recruited into PML bodies together with TP53.