Amino acid:1-37,with human FC tag.

C5AR1

C5a anaphylatoxin chemotactic receptor 1 (C5a anaphylatoxin chemotactic receptor) (C5a-R) (C5aR) (CD antigen CD88)

C5a anaphylatoxin chemotactic receptor 1 ;
C5a anaphylatoxin chemotactic receptor ;
C5a-R ;
C5aR ;
CD antigen CD88 ;
C5AR1 ;
C5AR ;
C5R1 ;

Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a (PubMed:10636859, PubMed:15153520, PubMed:1847994, PubMed:29300009, PubMed:7622471, PubMed:8182049, PubMed:9553099). The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events (PubMed:7622471, PubMed:8182049, PubMed:9553099). Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (PubMed:10636859, PubMed:15153520).

Cell membrane ; Multi-pass membrane protein . Cytoplasmic vesicle . Note=Phosphorylated C5aR colocalizes with ARRB1 and ARRB2 in cytoplasmic vesicles. .