BCL2L11

Bcl-2-like protein 11 ;
Bcl2-L-11 ;
Bcl2-interacting mediator of cell death ;

domain:The BH3 motif is required for Bcl-2 binding and cytotoxicity. ,function:Induces apoptosis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1 , isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis , although less potent than the isoforms BimEL , BimL and BimS. Isoform Bim-gamma induces apoptosis. ,similarity:Belongs to the Bcl-2 family. ,subcellular location:Associated with intracytoplasmic membranes. ,subunit:Forms heterodimers with a number of antiapoptotic Bcl-2 proteins including MCL1 , BCL2 , BCL2L1 isoform Bcl-X (L) , BCL2A1/BFL-1 , and BHRF1. Does not heterodimerize with proapoptotic proteins such as BAD , BOK , BAX or BAK. ,tissue specificity:Isoform BimEL , isoform BimL and isoform BimS are the predominant isoforms and are ubiquitously expressed with a tissue-specific variation. Isoform Bim-gamma is most abundantly expressed in small intestine and colon , and in lower levels in spleen , prostate , testis , heart , liver and kidney. ,

urogenital system development , in utero embryonic development , leukocyte homeostasis , B cell homeostasis , B cell apoptosis , kidney development , lymphocyte homeostasis , myeloid cell homeostasis , immune system development ,reproductive developmental process , apoptosis , induction of apoptosis , cell adhesion , cell-matrix adhesion , gamete generation , spermatogenesis , sensory organ development , sex differentiation , cell death , gonad development , male gonad development , induction of apoptosis by extracellular signals , activation of pro-apoptotic gene products , post-embryonic development , embryonic development ending in birth or egg hatching , post-embryonic morphogenesis ,regulation of cell death , positive regulation of cell death , programmed cell death , induction of programmed cell death ,death , sexual reproduction , biological adhesion , mammary gland development , cell-substrate adhesion , multicellular organism reproduction , tube lumen formation , tube morphogenesis , tube development , regulation of growth ,odontogenesis of dentine-containing tooth , odontogenesis , homeostatic process , regulation of apoptosis , chordate embryonic development , T cell homeostasis , positive regulation of apoptosis , regulation of programmed cell death ,positive regulation of programmed cell death , ear development , development of primary sexual characteristics ,development of primary male sexual characteristics , regulation of organ growth , male sex differentiation , regulation of pigmentation during development , male gamete generation , hemopoietic or lymphoid organ development , spleen development , thymus development , post-embryonic organ morphogenesis , post-embryonic organ development ,reproductive structure development , reproductive process in a multicellular organism , gland development ,homeostasis of number of cells , lymphocyte apoptosis ,

Endomembrane system ; Peripheral membrane protein . Associated with intracytoplasmic membranes. .; [Isoform BimEL]: Mitochondrion. Translocates from microtubules to mitochondria on loss of cell adherence.; [Isoform BimL]: Mitochondrion.; [Isoform BimS]: Mitochondrion.; [Isoform Bim-alpha1]: Mitochondrion.