BCL2L1 BCL2L BCLX

BCL2L1 ;
BCL2L ;
BCLX ;
Bcl-2-like protein 1 ;
Bcl2-L-1 ;
Apoptosis regulator Bcl-X

domain:The BH4 motif is required for anti-apoptotic activity. The BH1 and BH2 motifs are required for both heterodimerization with other Bcl-2 family members and for repression of cell death. ,function:Potent inhibitor of cell death. Isoform Bcl-X (L) anti-apoptotic activity is inhibited by association with SIVA isoform 1. Inhibits activation of caspases (By similarity) . Appears to regulate cell death by blocking the voltage-dependent anion channnel (VDAC) by binding to it and preventing the release of the caspase activator , cytochrome c , from the mitochondrial membrane. The Bcl-X (S) isoform promotes apoptosis. ,PTM:Proteolytically cleaved by caspases during apoptosis. The cleaved protein , lacking the BH4 motif , has pro-apoptotic activity. ,similarity:Belongs to the Bcl-2 family. ,subcellular location:Mitochondrial membranes and perinuclear envelope. ,subunit:Bcl-X (L) forms homodimers , and heterodimers with BAX , BAK and BCL2. Heterodimerization with BAX does not seem to be required for anti-apoptotic activity. Also interacts with BAD and BBC3. Isoform Bcl-X (L) binds to Siva isoform 1. Interacts with BCL2L11 (By similarity) . Interacts with BECN1 and PGAM5. Isoform Bcl-X (L) interacts with BAX isoform Sigma. ,tissue specificity:Bcl-X (S) is expressed at high levels in cells that undergo a high rate of turnover , such as developing lymphocytes. In contrast , Bcl-X (L) is found in tissues containing long-lived postmitotic cells , such as adult brain. ,

response to reactive oxygen species , ovarian follicle development , response to hypoxia , in utero embryonic development , release of cytochrome c from mitochondria , reproductive developmental process , mitochondrial transport , cellular ion homeostasis , apoptosis , anti-apoptosis , response to oxidative stress , mitochondrion organization , mitochondrial membrane organization , gamete generation , germ cell development , spermatogenesis ,sex differentiation , cell death , positive regulation of cell proliferation , gonad development , male gonad development ,female gonad development , negative regulation of survival gene product expression , apoptotic mitochondrial changes ,response to radiation , fertilization , response to abiotic stimulus , response to endogenous stimulus , response to hormone stimulus , embryonic development ending in birth or egg hatching , response to organic substance , response to inorganic substance , response to metal ion , response to organic nitrogen , response to lead ion , negative regulation of macromolecule metabolic process , negative regulation of gene expression , regulation of cell death ,positive regulation of cell death , programmed cell death , response to organic cyclic substance , response to cycloalkane , membrane organization , death , cellular homeostasis , sexual reproduction , ovulation cycle process ,multicellular organism reproduction , response to cytokine stimulus , growth , regulation of cell proliferation , regulation of membrane potential , response to hydrogen peroxide , homeostatic process , ovulation cycle , regulation of apoptosis ,chordate embryonic development , positive regulation of apoptosis , negative regulation of apoptosis , regulation of programmed cell death , positive regulation of programmed cell death , negative regulation of programmed cell death ,response to peptide hormone stimulus , regulation of neuron apoptosis , negative regulation of neuron apoptosis ,development of primary sexual characteristics , regulation of anti-apoptosis , positive regulation of anti-apoptosis ,regulation of survival gene product expression , development of primary female sexual characteristics , development of primary male sexual characteristics , female sex differentiation , male sex differentiation , response to cycloheximide ,regulation of mitochondrial membrane permeability , intracellular transport , male gamete generation , rhythmic process ,reproductive structure development , reproductive process in a multicellular organism , reproductive cellular process ,chemical homeostasis , ion homeostasis , response to protein stimulus , regulation of mitochondrial membrane potential ,cellular chemical homeostasis , negative regulation of cell death , response to oxygen levels ,

[Isoform Bcl-X (L) ]: Mitochondrion inner membrane . Mitochondrion outer membrane . Mitochondrion matrix . Cytoplasmic vesicle , secretory vesicle , synaptic vesicle membrane . Cytoplasm , cytosol . Cytoplasm , cytoskeleton , microtubule organizing center , centrosome. Nucleus membrane ; Single-pass membrane protein ; Cytoplasmic side . After neuronal stimulation , translocates from cytosol to synaptic vesicle and mitochondrion membrane in a calmodulin-dependent manner (By similarity) . Localizes to the centrosome when phosphorylated at Ser-49. .