ATF4

ATF4 ;
CREB2 ;
TXREB ;
Cyclic AMP-dependent transcription factor ATF-4 ;
cAMP-dependent transcription factor ATF-4 ;
Activating transcription factor 4 ;
Cyclic AMP-responsive element-binding protein 2 ;
CREB-2 ;
cAMP-responsive element-binding prot

function:Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3') , a sequence present in many viral and cellular promoters. It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. ,similarity:Belongs to the bZIP family. ,similarity:Contains 1 bZIP domain. ,subcellular location:Colocalizes with GABBR1 in hippocampal neuron dendritic membranes. ,subunit:Interacts with the C-terminal region of GABBR1 via the leucine zipper of its C-terminal bZIP domain. Interacts with the C-terminal region of GABBR2 (By similarity) . Binds DNA as a homo-or heterodimer. Interacts with the N-terminal region of CEP290. ,

monosaccharide metabolic process , glucose metabolic process , pyruvate metabolic process , gluconeogenesis ,transcription , regulation of transcription , DNA-dependent , regulation of transcription from RNA polymerase II promoter ,positive regulation of biosynthetic process , positive regulation of macromolecule biosynthetic process , positive regulation of macromolecule metabolic process , positive regulation of gene expression , carbohydrate biosynthetic process , hexose metabolic process , hexose biosynthetic process , positive regulation of cellular biosynthetic process ,cellular response to stress , cellular carbohydrate biosynthetic process , response to endoplasmic reticulum stress ,regulation of transcription , positive regulation of transcription , DNA-dependent , positive regulation of nucleobase , nucleoside , nucleotide and nucleic acid metabolic process , positive regulation of transcription , positive regulation of transcription from RNA polymerase II promoter , alcohol biosynthetic process , monosaccharide biosynthetic process ,positive regulation of nitrogen compound metabolic process , regulation of RNA metabolic process , positive regulation of RNA metabolic process ,

Nucleus . Nucleus speckle . Cytoplasm . Cell membrane . Cytoplasm , cytoskeleton , microtubule organizing center , centrosome . Colocalizes with GABBR1 in hippocampal neuron dendritic membranes (By similarity) . Colocalizes with NEK6 at the centrosome (PubMed:20873783) . Recruited to nuclear speckles following interaction with EP300/p300 (PubMed:16219772) . .