AKT2

RAC-beta serine/threonine-protein kinase

RAC-beta serine/threonine-protein kinase ;
Protein kinase Akt-2 ;
Protein kinase B beta ;
PKB beta ;
RAC-PK-beta ;

catalytic activity:ATP + a protein = ADP + a phosphoprotein. ,disease:Alterations of AKT2 may contribute to the pathogenesis of ovarian carcinomas. ,enzyme regulation:Two specific sites , one in the kinase domain (Thr-309) and the other in the C-terminal regulatory region (Ser-474) , need to be phosphorylated for its full activation. ,function:General protein kinase capable of phosphorylating several known proteins. ,similarity:Belongs to the protein kinase superfamily. ,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily. ,similarity:Contains 1 AGC-kinase C-terminal domain. ,similarity:Contains 1 PH domain. ,similarity:Contains 1 protein kinase domain. ,subunit:Interacts (via PH domain) with MTCP1 , TCL1A AND TCL1B. ,tissue specificity:In all human cell types so far analyzed. ,

regulation of sodium ion transport , regulation of glycogen biosynthetic process , regulation of carbohydrate metabolic process , protein amino acid phosphorylation , phosphorus metabolic process , phosphate metabolic process , cell surface receptor linked signal transduction , enzyme linked receptor protein signaling pathway , transmembrane receptor protein tyrosine kinase signaling pathway , insulin receptor signaling pathway , response to endogenous stimulus , response to hormone stimulus , positive regulation of biosynthetic process , regulation of catabolic process ,positive regulation of catabolic process , response to organic substance , positive regulation of macromolecule biosynthetic process , regulation of cellular ketone metabolic process , positive regulation of macromolecule metabolic process , regulation of protein kinase cascade , regulation of cellular carbohydrate metabolic process , positive regulation of cellular carbohydrate metabolic process , regulation of plasma membrane long-chain fatty acid transport ,negative regulation of plasma membrane long-chain fatty acid transport , positive regulation of sodium ion transport ,regulation of glucose transport , positive regulation of glucose transport , regulation of glucose metabolic process ,positive regulation of glucose metabolic process , regulation of metal ion transport , regulation of glucan biosynthetic process , phosphorylation , regulation of lipid metabolic process , regulation of fatty acid metabolic process , positive regulation of cellular biosynthetic process , regulation of cellular catabolic process , positive regulation of cellular catabolic process , regulation of fatty acid beta-oxidation , positive regulation of fatty acid beta-oxidation , regulation of lipid transport , negative regulation of lipid transport , response to insulin stimulus , cellular response to insulin stimulus ,cellular response to hormone stimulus , regulation of polysaccharide metabolic process , regulation of polysaccharide biosynthetic process , regulation of organic acid transport , negative regulation of organic acid transport , regulation of carbohydrate biosynthetic process , regulation of ion transport , positive regulation of ion transport , regulation of MAPKKK cascade , response to peptide hormone stimulus , regulation of generation of precursor metabolites and energy , positive regulation of glycogen biosynthetic process , positive regulation of lipid metabolic process , positive regulation of carbohydrate metabolic process , positive regulation of fatty acid metabolic process , regulation of fatty acid oxidation , positive regulation of fatty acid oxidation , regulation of glucose import , positive regulation of glucose import , regulation of JNK cascade , regulation of lipid catabolic process , positive regulation of lipid catabolic process ,positive regulation of transport , negative regulation of transport , regulation of stress-activated protein kinase signaling pathway , regulation of cellular response to stress ,

Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein. Early endosome . Localizes within both nucleus and cytoplasm of proliferative primary myoblasts and mostly within the nucleus of differentiated primary myoblasts. By virtue of the N-terminal PH domain , is recruited to sites of the plasma membrane containing increased PI (3 ,4 ,5) P3 or PI (3 ,4) P2 , cell membrane targeting is also facilitared by interaction with CLIP3. Colocalizes with WDFY2 in early endosomes (By similarity) . .