ABL1

Abelson tyrosine-protein kinase 2 ;
Abelson murine leukemia viral oncogene homolog 2 ;
Abelson-related gene protein ;
Tyrosine-protein kinase ARG ;

catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. ,caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. ,cofactor:Magnesium or manganese. ,enzyme regulation:Stabilized in the inactive form by an association between the SH3 domain and the SH2-TK linker region , interactions of the amino-terminal cap , and contributions from an amino-terminal myristoyl group and phospholipids. Activated by autophosphorylation as well as by SRC-family kinase-mediated phosphorylation. Activated by RIN1 binding to the SH2 and SH3 domains. Inhibited by imatinib mesylate (Gleevec) which is used for the treatment of chronic myeloid leukemia (CML) . ,function:Regulates cytoskeleton remodeling during cell differentiation , cell division and cell adhesion. Localizes to dynamic actin structures , and phosphorylates CRK and CRKL , DOK1 , and other proteins controlling cytoskeleton dynamics. ,PTM:Phosphorylated upon DNA damage , probably by ATM or ATR. ,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. ,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. ABL subfamily. ,similarity:Contains 1 protein kinase domain. ,similarity:Contains 1 SH2 domain. ,similarity:Contains 1 SH3 domain. ,tissue specificity:Widely expressed. ,

protein amino acid phosphorylation , phosphorus metabolic process , phosphate metabolic process , cytoskeleton organization , actin filament organization , cell adhesion , phosphorylation , peptidyl-tyrosine phosphorylation , peptidyl-tyrosine modification , biological adhesion , actin filament-based process , actin cytoskeleton organization , positive regulation of catalytic activity , positive regulation of molecular function , actin filament bundle formation , regulation of oxidoreductase activity , positive regulation of oxidoreductase activity ,

Cytoplasm , cytoskeleton.