HCLS1

Hematopoietic lineage cell-specific protein ;
Hematopoietic cell-specific LYN substrate 1 ;
LckBP1 ;
p75 ;

developmental stage:Expressed in early stage of myeloid and erythroid differentiation. ,function:Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression. ,PTM:Phosphorylated by LYN; rapidly after cross-linking of surface IgM on B-cells. ,similarity:Contains 1 SH3 domain. ,similarity:Contains 4 cortactin repeats. ,subunit:Associates with the SH2 and SH3 domains of LCK. Binding to he LCK SH3 domain occurs constitutively , while binding to the LCK SH2 domain occurs only upon TCR stimulation. A similar binding pattern was observed with LYN , but not with FYN in which the FYN SH2 region associates upon TCR stimulation but the FYN SH3 region does not associate regardless of TCR stimulation. Directly associates with HAX1 , through binding to its C-terminal region. Interacts with HS1BP3. ,tissue specificity:Expressed only in tissues and cells of hematopoietic origin. ,

regulation of protein amino acid phosphorylation , positive regulation of protein amino acid phosphorylation , immune system development , regulation of transcription , DNA-dependent , intracellular signaling cascade , positive regulation of cell proliferation , response to endogenous stimulus , response to hormone stimulus , positive regulation of signal transduction , response to organic substance , positive regulation of phosphorus metabolic process , positive regulation of macromolecule metabolic process , regulation of protein kinase cascade , positive regulation of cell communication ,positive regulation of protein kinase cascade , regulation of phosphate metabolic process , hemopoiesis , myeloid cell differentiation , erythrocyte differentiation , regulation of protein modification process , positive regulation of protein modification process , regulation of cellular protein metabolic process , positive regulation of cellular protein metabolic process , erythrocyte homeostasis , regulation of cell proliferation , regulation of phosphorylation , positive regulation of phosphorylation , regulation of tyrosine phosphorylation of STAT protein , positive regulation of tyrosine phosphorylation of STAT protein , homeostatic process , regulation of transcription , positive regulation of phosphate metabolic process , regulation of JAK-STAT cascade , positive regulation of JAK-STAT cascade , hemopoietic or lymphoid organ development , homeostasis of number of cells , regulation of peptidyl-tyrosine phosphorylation , positive regulation of peptidyl-tyrosine phosphorylation , regulation of phosphorus metabolic process , positive regulation of protein metabolic process , regulation of RNA metabolic process ,

Membrane ; Peripheral membrane protein . Cytoplasm . Mitochondrion .