TOB1

Protein Tob1 ;
Transducer of erbB-2 1 ;

function:Anti-proliferative protein that interacts with the erbB-2 receptor tyrosine kinase. May physically and/or functionally interact with protein-tyrosine kinase receptors. ,PTM:Phosphorylated on Ser and Thr residues. ,similarity:Belongs to the BTG family. ,subunit:Interacts with CNOT7. ,tissue specificity:Ubiquitous. ,

protein import into nucleus , translocation , protein targeting , protein import into nucleus , intracellular protein transport ,nucleocytoplasmic transport , cell surface receptor linked signal transduction , enzyme linked receptor protein signaling pathway , transmembrane receptor protein serine/threonine kinase signaling pathway , SMAD protein nuclear translocation , protein localization , negative regulation of cell proliferation , negative regulation of signal transduction ,negative regulation of cell communication , protein transport , protein import , regulation of ossification , regulation of BMP signaling pathway , negative regulation of BMP signaling pathway , protein localization in organelle , protein localization in nucleus , cellular protein localization , regulation of cell proliferation , establishment of protein localization ,negative regulation of cell differentiation , regulation of osteoblast differentiation , negative regulation of osteoblast differentiation , intracellular transport , nuclear transport , nuclear import , cellular macromolecule localization ,

Cytoplasm . Nucleus . Only a small fraction localizes to the cytoplasm except in late S-phase where more than half of proteins become cytoplasmic. .