RFA2 (Phospho Ser33) Cell-Based Colorimetric ELISA Kit
-KA1758C
主要信息
Reactivity
Human, Mouse, Rat
Applications
ELISA
Conjugate/Modification
Phospho
详细信息
储存
2-8°C/6 months,Ship by ice bag
修饰
Phospho
检测方法
Colorimetric
相关产品
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RPA32/RPA2 Rabbit pAb
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Primary Antibodies
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Primary Antibodies
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RPA32/RPA2 (Phospho Ser33) Rabbit pAb
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ELISA Kits
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ELISA Kits
RFA2 (Phospho Ser33) Cell-Based Colorimetric ELISA Kit
KA1758C
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ELISA Kits
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抗原&靶点信息
基因名称:
RFA2
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别名:
Replication protein A 32 kDa subunit ;
RP-A p32 ;
Replication factor A protein 2 ;
RF-A protein 2 ;
Replication protein A 34 kDa subunit ;
RP-A p34 ;
RP-A p32 ;
Replication factor A protein 2 ;
RF-A protein 2 ;
Replication protein A 34 kDa subunit ;
RP-A p34 ;
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背景:
function:Required for DNA recombination , repair and replication. The activity of RP-A is mediated by single-stranded DNA binding and protein interactions. ,PTM:Phosphorylated in a cell-cycle-dependent manner (from the S phase until mitosis) . Phosphorylated by ATR upon DNA damage , which promotes its translocation to nuclear foci. Can be phosphorylated in vitro by PRKDC/DNA-PK in the presence of Ku and DNA , and by CDC2. ,subcellular location:Also present in PML nuclear bodies. Redistributes to discrete nuclear foci upon DNA damage. ,subunit:Heterotrimer of 70 , 32 and 14 kDa chains. The DNA-binding activity may reside exclusively on the 70 kDa subunit. Binds to SERTAD3/RBT1. Interacts with TIPIN. ,
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功能:
nucleotide-excision repair , DNA damage removal , DNA metabolic process , DNA replication , DNA-dependent DNA replication , DNA repair , nucleotide-excision repair , nucleotide-excision repair , DNA gap filling , DNA catabolic process ,response to DNA damage stimulus , macromolecule catabolic process , cellular response to stress , cellular macromolecule catabolic process ,
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细胞定位:
Nucleus . Nucleus , PML body . Redistributes to discrete nuclear foci upon DNA damage in an ATR-dependent manner. .
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