NUDC

Nuclear migration protein nudC ;
Nuclear distribution protein C homolog ;

function:Plays a role in neurogenesis and neuronal migration (By similarity) . Necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Necessary for cytokinesis and cell proliferation. ,induction:Up-regulated in actively dividing hematopoietic precursor cells. Up-regulated in cultured erythroleukemia TF-1 cells by granulocyte-macrophage colony-stimulating factor. Strongly down-regulated during maturation of erythroid precursor cells. ,PTM:Reversibly phosphorylated on serine residues during the M phase of the cell cycle. Phosphorylation on Ser-274 and Ser-326 is necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Phosphorylated by PLK and other kinases. ,similarity:Belongs to the nudC family. ,similarity:Contains 1 CS domain. ,subcellular location:In a filamentous pattern adjacent to the nucleus of migrating cerebellar granule cells. Colocalizes with tubulin and dynein and with the microtubule organizing center. Distributed throughout the cytoplasm of non-migrating cells. A small proportion is nuclear , in a punctate pattern. ,subunit:Binds PLK1. Binds PAFAH1B1 (By similarity) . Part of a complex containing PLK1 , NUDC , dynein and dynactin. ,tissue specificity:Ubiquitous. Highly expressed in fetal liver , kidney , lung and brain. Highly expressed in adult pancreas , kidney , skeletal muscle , liver , lung , placenta , prostate , brain and heart. ,

M phase of mitotic cell cycle , mitotic cell cycle , M phase , nuclear division , cell cycle , mitosis , nuclear migration , cell proliferation , response to endogenous stimulus , response to hormone stimulus , response to organic substance , cell cycle process , cell cycle phase , establishment of nucleus localization , response to peptide hormone stimulus , organelle fission , cell division , organelle localization , nucleus localization , establishment of organelle localization ,

Cytoplasm , cytoskeleton. Nucleus . Cytoplasm , cytoskeleton , spindle . Midbody . In a filamentous pattern adjacent to the nucleus of migrating cerebellar granule cells. Colocalizes with tubulin and dynein and with the microtubule organizing center. Distributed throughout the cytoplasm of non-migrating cells. A small proportion is nuclear , in a punctate pattern. Localizes to the mitotic spindle in a EML4-dependent manner (PubMed:25789526) . .