Detects endogenous levels of MKP-1/2 only when phosphorylated at Human:S296/318, Mouse:S296/322, Rat:S296/319.

DUSP1/4

catalytic activity:A phosphoprotein + H (2) O = a protein + phosphate. ,catalytic activity:Protein tyrosine phosphate + H (2) O = protein tyrosine + phosphate. ,function:Dual specificity phosphatase that dephosphorylates MAP kinase ERK2 on both 'Thr-183' and 'Tyr-185'. ,induction:By oxidative stress and heat shock. ,similarity:Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. ,similarity:Contains 1 rhodanese domain. ,similarity:Contains 1 tyrosine-protein phosphatase domain. ,tissue specificity:Expressed at high levels in the lung , liver placenta and pancreas. Moderate levels seen in the heart and skeletal muscle. Lower levels found in the brain and kidney. ,

response to reactive oxygen species , protein amino acid dephosphorylation , phosphorus metabolic process ,phosphate metabolic process , response to oxidative stress , cell cycle , intracellular signaling cascade , response to nutrient , response to radiation , response to light stimulus , response to abiotic stimulus , response to endogenous stimulus , response to hormone stimulus , response to extracellular stimulus , response to organic substance , response to inorganic substance , response to metal ion , regulation of cell death , positive regulation of cell death ,dephosphorylation , response to nutrient levels , response to corticosteroid stimulus , response to estradiol stimulus ,response to retinoic acid , cellular response to hormone stimulus , response to vitamin A , response to vitamin , response to testosterone stimulus , response to hydrogen peroxide , regulation of apoptosis , positive regulation of apoptosis ,regulation of programmed cell death , positive regulation of programmed cell death , response to estrogen stimulus ,regulation of anti-apoptosis , positive regulation of anti-apoptosis , response to steroid hormone stimulus , response to glucocorticoid stimulus , response to cAMP , response to calcium ion ,

Nucleus .