MEF2C

Myocyte-specific enhancer factor 2C

alternative products:Additional isoforms seem to exist ,developmental stage:Expression is highest during the early stages of postnatal development , at later stages levels greatly decrease. ,domain:The beta domain , missing in a number of isoforms , is required for enhancement of transcriptional activity. ,function:Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis , and is also involved in vascular development. May also be involved in neurogenesis and in the development of cortical architecture (By similarity) . Isoform 3 and isoform 4 , which lack the repressor domain , are more active than isoform 1 and isoform 2. ,PTM:Acetylated by p300 on several sites in diffentiating myocytes. Acetylation on Lys-4 increases DNA binding and transactivation. ,PTM:Phosphorylation on Ser-59 enhances DNA binding activity (By similarity) . Phosphorylation on Ser-396 is required for Lys-391 sumoylation and inhibits transcriptional activity. ,PTM:Proteolytically cleaved in cerebellar granule neurons , probably by caspase 7 , following neurotoxicity. Preferentially cleaves the CDK5-mediated hyperphosphorylated form which leads to neuron apoptosis and transcriptional inactivation. ,PTM:Sumoylated on Lys-391 by SUMO2 but not by SUMO1 represses transcriptional activity. ,similarity:Belongs to the MEF2 family. ,similarity:Contains 1 MADS-box domain. ,similarity:Contains 1 Mef2-type DNA-binding domain. ,subunit:Forms a complex with class II HDACs in undifferentiating cells. On myogenic differentiation , HDACs are released into the cytoplasm allowing MEF2s to interact with other proteins for activation. Interacts with EP300 in differentiating cells; the interaction acetylates MEF2C leading to increased DNA binding and activation. Interacts with HDAC7 and CARM1 (By similarity) . Interacts with HDAC4 , HDAC7 AND HDAC9; the interaction WITH HDACs represses transcriptional activity. ,tissue specificity:Expressed in brain and skeletal muscle. ,

negative regulation of transcription from RNA polymerase II promoter , transcription , regulation of transcription , DNA-dependent , regulation of transcription from RNA polymerase II promoter , apoptosis , anti-apoptosis , muscle organ development , cell death , negative regulation of biosynthetic process , positive regulation of biosynthetic process ,regulation of specific transcription from RNA polymerase II promoter , positive regulation of specific transcription from RNA polymerase II promoter , negative regulation of specific transcription from RNA polymerase II promoter , positive regulation of macromolecule biosynthetic process , negative regulation of macromolecule biosynthetic process , positive regulation of macromolecule metabolic process , negative regulation of macromolecule metabolic process , positive regulation of gene expression , negative regulation of gene expression , regulation of cell death , programmed cell death , death , negative regulation of transcription , negative regulation of cellular biosynthetic process , positive regulation of cellular biosynthetic process , negative regulation of gene-specific transcription , regulation of gene-specific transcription , regulation of apoptosis , negative regulation of apoptosis , regulation of programmed cell death ,negative regulation of programmed cell death , positive regulation of gene-specific transcription , regulation of transcription , regulation of survival gene product expression , positive regulation of survival gene product expression ,negative regulation of transcription , DNA-dependent , positive regulation of transcription , DNA-dependent , negative regulation of nucleobase , nucleoside , nucleotide and nucleic acid metabolic process , positive regulation of nucleobase , nucleoside , nucleotide and nucleic acid metabolic process , positive regulation of transcription , positive regulation of transcription from RNA polymerase II promoter , negative regulation of nitrogen compound metabolic process , positive regulation of nitrogen compound metabolic process , regulation of RNA metabolic process , negative regulation of RNA metabolic process , positive regulation of RNA metabolic process , negative regulation of cell death ,

Nucleus . Cytoplasm , sarcoplasm .