MAPKAPK5 (Phospho Thr182) Cell-Based Colorimetric ELISA Kit
-KA1752C
主要信息
Reactivity
Human, Mouse
Applications
ELISA
Conjugate/Modification
Phospho
详细信息
储存
2-8°C/6 months,Ship by ice bag
修饰
Phospho
检测方法
Colorimetric
相关产品
Primary Antibodies
MAPKAPK5 Rabbit pAb
YT3848
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Primary Antibodies
MAPKAPK5 (Phospho Thr182) Rabbit pAb
YP0820
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ELISA Kits
Total MAPKAPK5 Cell-Based Colorimetric ELISA Kit
KA4169C
预览→
ELISA Kits
MAPKAPK5 (Phospho Thr182) Cell-Based Colorimetric ELISA Kit
KA1752C
预览→
抗原&靶点信息
基因名称:
MAPKAPK5
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别名:
MAPKAPK5 ;
PRAK ;
MAP kinase-activated protein kinase 5 ;
MAPK-activated protein kinase 5 ;
MAPKAP kinase 5 ;
MAPKAP-K5 ;
MAPKAPK-5 ;
MK-5 ;
MK5 ;
p38-regulated/activated protein kinase ;
PRAK
PRAK ;
MAP kinase-activated protein kinase 5 ;
MAPK-activated protein kinase 5 ;
MAPKAP kinase 5 ;
MAPKAP-K5 ;
MAPKAPK-5 ;
MK-5 ;
MK5 ;
p38-regulated/activated protein kinase ;
PRAK
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背景:
catalytic activity:ATP + a protein = ADP + a phosphoprotein. ,enzyme regulation:p38 alpha and beta-dependent phosphorylation increases its activity. Activated by stress-related extracellular stimuli; such as H (2) O (2) , arsenite , anisomycin TNF alpha and also PMA and the calcium ionophore A23187; but to a lesser extent. In vitro , activated by SQSTM1. ,function:Mediates stress-induced small heat shock protein 27 phosphorylation. ,PTM:Phosphorylated on Thr-182; which is the regulatory phosphorylation site and is located on the T-loop/loop 12. ,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. ,similarity:Contains 1 protein kinase domain. ,subcellular location:Also observed in the nucleus. ,subunit:Interacts with SQSTM1. ,tissue specificity:Expressed ubiquitously. ,
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功能:
protein amino acid phosphorylation , phosphorus metabolic process , phosphate metabolic process , phosphorylation ,
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细胞定位:
Cytoplasm. Nucleus. Translocates to the cytoplasm following phosphorylation and activation. Interaction with ERK3/MAPK6 or ERK4/MAPK4 and phosphorylation at Thr-182 , activates the protein kinase activity , followed by translocation to the cytoplasm. Phosphorylation by PKA/PRKACA at Ser-115 also induces nuclear export.
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