CTBP1

C-terminal-binding protein 1 ;
CtBP1 ;

cofactor:NAD. Required for efficient interaction with E1A. Cofactor binding induces a conformation change. ,function:Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex (By similarity) . Co-repressor targeting diverse transcription regulators such as GLIS2. Has dehydrogenase activity. ,PTM:ADP-ribosylated; when cells are exposed to brefeldin-A (BFA) . ,PTM:Sumoylation on Lys-428 is promoted by the E3 SUMO-protein ligase CBX4. ,PTM:The level of phosphorylation appears to be regulated during the cell cycle. Phosphorylated upon DNA damage , probably by ATM or ATR. Phosphorylation by HIPK2 on Ser-422 induces proteasomal degradation. ,similarity:Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. ,subunit:Interacts with the C-terminus of adenovirus E1A protein , ELK3 and CTIP via their consensus motif P-X-[DNS]-L-[STVA]. Can form homodimers or heterodimers of CTBP1 and CTBP2. Interacts with FOXP2 , HDAC4 , HDAC5 and HDAC9. Interacts with GLIS2 but not GLIS1 or GLIS3 (By similarity) . Interacts with FOXP1 , HIPK2 , PNN and NRIP1. Interacts with ZFHX1B and WIZ. Interacts with Epstein-Barr virus EBNA3 and EBNA6. ,

negative regulation of transcription from RNA polymerase II promoter , regulation of transcription , DNA-dependent ,regulation of transcription from RNA polymerase II promoter , protein amino acid phosphorylation , phosphorus metabolic process , phosphate metabolic process , Golgi organization , negative regulation of cell proliferation , negative regulation of biosynthetic process , negative regulation of macromolecule biosynthetic process , negative regulation of macromolecule metabolic process , negative regulation of gene expression , viral reproduction , phosphorylation ,negative regulation of transcription , viral infectious cycle , viral genome replication , viral reproductive process , negative regulation of cellular biosynthetic process , regulation of cell proliferation , fat cell differentiation , regulation of transcription , negative regulation of transcription , DNA-dependent , negative regulation of nucleobase , nucleoside , nucleotide and nucleic acid metabolic process , white fat cell differentiation , negative regulation of nitrogen compound metabolic process , regulation of RNA metabolic process , negative regulation of RNA metabolic process , oxidation reduction ,

Cytoplasm . Nucleus .