CBX3

Chromobox protein homolog 3 ;
HECH ;
Heterochromatin protein 1 homolog gamma ;
HP1 gamma ;
Modifier 2 protein ;

function:Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9' , leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR) . Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. ,PTM:Phosphorylated by PIM1. Phosphorylated during interphase and possibly hyper-phosphorylated during mitosis. ,similarity:Contains 2 chromo domains. ,subcellular location:Associates with euchromatin and is largely excluded from constitutive heterochromatin. May be associated with microtubules and mitotic poles during mitosis. ,subunit:Binds directly to CHAF1A. Interacts with histone H3 methylated at 'Lys-9'. Part of the E2F6.com-1 complex in G0 phase composed of E2F6 , MGA , MAX , TFDP1 , CBX3 , BAT8 , EUHMTASE1 , RING1 , RNF2 , MBLR , L3MBTL2 and YAF2. Interacts with LBR , INCENP , TRIM28/TIF1B , SUV420H1 , SUV420H2 and SP100. Interacts with TIF1A (By similarity) . Interacts with MIS12 and C20orf127. Can interact directly with CBX5 via the chromoshadow domain. ,

chromatin organization , chromatin assembly or disassembly , chromatin remodeling , transcription , regulation of transcription , DNA-dependent , negative regulation of biosynthetic process , negative regulation of macromolecule biosynthetic process , negative regulation of macromolecule metabolic process , negative regulation of gene expression , negative regulation of transcription , chromatin modification , negative regulation of cellular biosynthetic process , regulation of transcription , negative regulation of transcription , DNA-dependent , negative regulation of nucleobase , nucleoside , nucleotide and nucleic acid metabolic process , negative regulation of nitrogen compound metabolic process , regulation of RNA metabolic process , negative regulation of RNA metabolic process , chromosome organization ,

Nucleus . Associates with euchromatin and is largely excluded from constitutive heterochromatin. May be associated with microtubules and mitotic poles during mitosis (Potential) . .