TOP2A (Phospho Thr1343) Cell-Based Colorimetric ELISA Kit
-KA1729C
主要信息
Reactivity
Human
Applications
ELISA
Conjugate/Modification
Phospho
详细信息
储存
2-8°C/6 months,Ship by ice bag
修饰
Phospho
检测方法
Colorimetric
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抗原&靶点信息
基因名称:
TOP2A TOP2
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别名:
TOP2A ;
TOP2 ;
DNA topoisomerase 2-alpha ;
DNA topoisomerase II ;
alpha isozyme
TOP2 ;
DNA topoisomerase 2-alpha ;
DNA topoisomerase II ;
alpha isozyme
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背景:
catalytic activity:ATP-dependent breakage , passage and rejoining of double-stranded DNA. ,enzyme regulation:Specifically inhibited by the intercalating agent amsacrine. ,function:Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. ,miscellaneous:Eukaryotic topoisomerase I and II can relax both negative and positive supercoils , whereas prokaryotic enzymes relax only negative supercoils. ,PTM:Phosphorylation has no effect on catalytic activity. ,similarity:Belongs to the type II topoisomerase family. ,subcellular location:Generally located in the nucleoplasm. ,subunit:Homodimer. Interacts with COPS5. ,
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功能:
DNA metabolic process , DNA replication , DNA topological change , DNA ligation , DNA repair , DNA packaging , apoptosis ,response to DNA damage stimulus , nucleus organization , chromosome segregation , intracellular signaling cascade , cell death , regulation of cell death , positive regulation of cell death , programmed cell death , death , second-messenger-mediated signaling , chromosome condensation , apoptotic nuclear changes , apoptotic chromosome condensation ,cellular response to stress , regulation of apoptosis , positive regulation of apoptosis , regulation of programmed cell death , positive regulation of programmed cell death , regulation of viral genome replication , positive regulation of viral genome replication , regulation of retroviral genome replication , positive regulation of retroviral genome replication ,phosphoinositide-mediated signaling , positive regulation of viral reproduction , regulation of viral reproduction ,chromosome organization ,
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细胞定位:
Cytoplasm . Nucleus , nucleoplasm . Nucleus . Nucleus , nucleolus .
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