RIPK2 CARDIAK RICK RIP2 UNQ277/PRO314/PRO34092

Receptor-interacting serine/threonine-protein kinase 2 (CARD-containing interleukin-1 beta-converting enzyme-associated kinase) (CARD-containing IL-1 beta ICE-kinase) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (Tyrosine-protein kinase RIPK2) (EC 2.7.10.2)

Receptor-interacting serine/threonine-protein kinase 2 ;
CARD-containing interleukin-1 beta-converting enzyme-associated kinase ;
CARD-containing IL-1 beta ICE-kinase ;
RIP-like-interacting CLARP kinase ;
Receptor-interacting protein 2 ;
RIP-2 ;
Tyrosine-protein kinase RIPK2 ;

catalytic activity:ATP + a protein = ADP + a phosphoprotein. ,function:Activates pro-caspase-1 and pro-caspase-8. Potentiates CASP8-mediated apoptosis. Activates NF-kappa-B. ,PTM:Autophosphorylated. Phosphorylated upon DNA damage , probably by ATM or ATR. ,similarity:Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. ,similarity:Contains 1 CARD domain. ,similarity:Contains 1 protein kinase domain. ,subunit:Binds to CFLAR/CLARP and CASP1 via their CARD domains. Binds to BIRC3/c-IAP1 and BIRC2/c-IAP2 , TRAF1 , TRAF2 , TRAF5 and TRAF6. May be a component of both the TNFRSF1A and TNRFSF5/CD40 receptor complex. ,tissue specificity:Detected in heart , brain , placenta , lung , peripheral blood leukocytes , spleen , kidney , testis , prostate , pancreas and lymph node. ,

cell activation , regulation of cytokine production , positive regulation of cytokine production , activation of innate immune response , pattern recognition receptor signaling pathway , toll-like receptor signaling pathway , response to molecule of bacterial origin , activation of immune response , immune response-activating cell surface receptor signaling pathway , positive regulation of immune system process , regulation of leukocyte activation , positive regulation of leukocyte activation , immune response-activating signal transduction , innate immune response-activating signal transduction , immune response-regulating signal transduction , immune response-regulating cell surface receptor signaling pathway , protein amino acid phosphorylation , phosphorus metabolic process , phosphate metabolic process ,apoptosis , anti-apoptosis , defense response , inflammatory response , cell surface receptor linked signal transduction ,cell death , cell proliferation , positive regulation of cell proliferation , response to wounding , response to bacterium ,positive regulation of signal transduction , response to organic substance , regulation of protein kinase cascade ,positive regulation of cell communication , positive regulation of protein kinase cascade , regulation of cell death ,positive regulation of cell death , programmed cell death , death , phosphorylation , positive regulation of defense response , lipopolysaccharide-mediated signaling pathway , response to peptidoglycan , response to lipopolysaccharide ,regulation of chemokine production , regulation of interferon-gamma production , regulation of interleukin-2 production ,regulation of interleukin-6 production , regulation of tumor necrosis factor production , positive regulation of chemokine production , positive regulation of interferon-gamma production , positive regulation of interleukin-2 production , positive regulation of interleukin-6 production , positive regulation of tumor necrosis factor production , regulation of stress-activated MAPK cascade , positive regulation of stress-activated MAPK cascade , mononuclear cell proliferation ,regulation of mononuclear cell proliferation , positive regulation of mononuclear cell proliferation , regulation of immature T cell proliferation , positive regulation of immature T cell proliferation , response to cytokine stimulus , toll-like receptor 2 signaling pathway , toll-like receptor 4 signaling pathway , T cell proliferation , positive regulation of T cell proliferation , T cell activation , regulation of cell proliferation , regulation of T cell proliferation , defense response to bacterium , regulation of apoptosis , positive regulation of apoptosis , negative regulation of apoptosis , regulation of programmed cell death , positive regulation of programmed cell death , negative regulation of programmed cell death ,regulation of I-kappaB kinase/NF-kappaB cascade , positive regulation of I-kappaB kinase/NF-kappaB cascade ,response to exogenous dsRNA , response to dsRNA , positive regulation of DNA binding , regulation of MAPKKK cascade ,positive regulation of MAPKKK cascade , positive regulation of molecular function , regulation of innate immune response , positive regulation of innate immune response , leukocyte activation , regulation of transcription , regulation of JNK cascade , positive regulation of JNK cascade , regulation of alpha-beta T cell activation , positive regulation of alpha-beta T cell activation , regulation of alpha-beta T cell proliferation , positive regulation of alpha-beta T cell proliferation , lymphocyte activation , lymphocyte proliferation , positive regulation of response to stimulus , regulation of lymphocyte proliferation , positive regulation of lymphocyte proliferation , positive regulation of immune response ,defense response to Gram-positive bacterium , antigen receptor-mediated signaling pathway , T cell receptor signaling pathway , regulation of T cell activation , regulation of cell activation , positive regulation of cell activation , positive regulation of T cell activation , regulation of transcription factor activity , positive regulation of transcription factor activity , positive regulation of NF-kappaB transcription factor activity , regulation of binding , positive regulation of binding , regulation of DNA binding , positive regulation of multicellular organismal process , regulation of lymphocyte activation , positive regulation of lymphocyte activation , negative regulation of cell death , regulation of stress-activated protein kinase signaling pathway , positive regulation of stress-activated protein kinase signaling pathway , regulation of ERK1 and ERK2 cascade , positive regulation of ERK1 and ERK2 cascade , response to lipoteichoic acid , nucleotide-binding oligomerization domain containing signaling pathway , nucleotide-binding oligomerization domain containing 1 signaling pathway , nucleotide-binding oligomerization domain containing 2 signaling pathway , response to interleukin-1 , leukocyte proliferation , regulation of leukocyte proliferation , positive regulation of leukocyte proliferation , regulation of cellular response to stress ,

Cytoplasm .