PRKCB

PRKCB ;
PKCB ;
PRKCB1 ;
Protein kinase C beta type ;
PKC-B ;
PKC-beta

catalytic activity:ATP + a protein = ADP + a phosphoprotein. ,cofactor:Binds 3 calcium ions per subunit. The ions are bound to the C2 domain. ,function:This is a calcium-activated , phospholipid-dependent , serine- and threonine-specific enzyme. PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters , a class of tumor promoters. May be considered as a novel component of the NF-kappa-B signaling axis responsible for the survival and activation of B-cells after BCR cross-linking. ,PTM:Phosphorylation on Thr-500 of isoform beta-I , within the activation loop , renders it competent to autophosphorylate. Subsequent autophosphorylation of Thr-642 maintains catalytic competence , and autophosphorylation on Ser-661 appears to release the kinase into the cytosol. Similarly , isoform beta-II is autophosphorylated on 'Thr-640' and 'Ser-659' , subsequent to phosphorylation on Thr-500. Autophosphorylated on other sites i.e. in the N-terminal and hinge regions have no effect on PKC activity. ,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. ,similarity:Contains 1 AGC-kinase C-terminal domain. ,similarity:Contains 1 C2 domain. ,similarity:Contains 1 protein kinase domain. ,similarity:Contains 2 phorbol-ester/DAG-type zinc fingers. ,subunit:Interacts with PDK1 (By similarity) . Interacts in vitro with PRKCBP1. ,

protein amino acid phosphorylation , phosphorus metabolic process , phosphate metabolic process , ion transport ,cation transport , calcium ion transport , cellular ion homeostasis , cellular calcium ion homeostasis , cellular metal ion homeostasis , intracellular signaling cascade , protein localization , protein transport , di- , tri-valent inorganic cation transport , phosphorylation , cellular homeostasis , metal ion transport , cellular cation homeostasis , cellular di- , tri-valent inorganic cation homeostasis , homeostatic process , lipoprotein transport , establishment of protein localization ,chemical homeostasis , ion homeostasis , metal ion homeostasis , di- , tri-valent inorganic cation homeostasis , calcium ion homeostasis , cation homeostasis , cellular chemical homeostasis ,

Cytoplasm . Nucleus . Membrane ; Peripheral membrane protein .