MAP2K7

Dual specificity mitogen-activated protein kinase kinase 7 ;
MAP kinase kinase 7 ;
MAPKK 7 ;
JNK-activating kinase 2 ;
MAPK/ERK kinase 7 ;
MEK 7 ;
Stress-activated protein kinase kinase 4 ;
SAPK kinase 4 ;
SAPKK-4 ;
SAPKK4 ;
c-Jun N-terminal kinase kinase 2 ;
JNK kinase 2 ;
JNKK 2 ;

catalytic activity:ATP + a protein = ADP + a phosphoprotein. ,cofactor:Magnesium. ,enzyme regulation:Activated by phosphorylation by specific MAP kinase kinase kinases such as MAP3K1/MEKK1 , MAP3K3/MEKK3 , MAP3K11/MLK3 and MAP3K12/DLK. ,function:Stress activated , dual specificity kinase that activates the JUN kinases MAPK8/JNK1 , MAPK9/JNK2 and MAPK10/JNK3. ,PTM:Activated by phosphorylation on Ser/Thr. ,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. ,similarity:Contains 1 protein kinase domain. ,tissue specificity:Ubiquitous; with highest level of expression in skeletal muscle. Isoform 3 is found at low levels in placenta , fetal liver , and skeletal muscle. ,

MAPKKK cascade , protein amino acid phosphorylation , phosphorus metabolic process , phosphate metabolic process ,intracellular signaling cascade , protein kinase cascade , phosphorylation , stress-activated protein kinase signaling pathway , cellular response to stress , stress-activated MAPK cascade ,

Nucleus. Cytoplasm .