FRS2

Fibroblast growth factor receptor substrate 2 ;
FGFR substrate 2 ;
FGFR-signaling adaptor SNT ;
Suc1-associated neurotrophic factor target 1 ;
SNT-1 ;

function:Adapter protein that links FGR and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Modulates signaling via SHC1 by competing for a common binding site on NTRK1. ,PTM:Phosphorylated on tyrosine residues upon stimulation by NGF. ,PTM:Ubiquitinated when tyrosine phosphorylated and in a complex with GRB2. The unphosphorylated form is not subject to ubiquitination. ,sequence caution:Translated as stop. ,similarity:Contains 1 IRS-type PTB domain. ,subcellular location:Cytoplasmic , membrane-bound. ,subunit:Part of a complex containing FRS2 , GRB2 and SOS1. Part of a complex containing GRB2 and CBL. Binds RET (By similarity) . Binds FGFR1 , SUC1 , NTRK1 , NTRK2 , NTRK3 and SRC. The tyrosine-phosphorylated protein binds the SH2 domains of GRB2 and PTPN11. ,tissue specificity:Highly expressed in heart , brain , spleen , lung , liver , skeletal muscle , kidney and testis. ,

MAPKKK cascade , activation of MAPK activity , embryonic axis specification , eye development , gastrulation with mouth forming second , cell fate specification , optic placode formation , induction of an organ , regionalization , protein amino acid phosphorylation , phosphorus metabolic process , phosphate metabolic process , cell surface receptor linked signal transduction , enzyme linked receptor protein signaling pathway , transmembrane receptor protein tyrosine kinase signaling pathway , transmembrane receptor protein tyrosine phosphatase signaling pathway , G-protein coupled receptor protein signaling pathway , intracellular signaling cascade , protein kinase cascade , cell-cell signaling ,blastoderm segmentation , tripartite regional subdivision , gastrulation , pattern specification process , neuroblast proliferation , sensory organ development , cell proliferation , fibroblast growth factor receptor signaling pathway ,determination of anterior/posterior axis , embryo , axis specification , embryonic pattern specification , anterior/posterior axis specification , anterior/posterior pattern formation , phosphorylation , regulation of phosphate metabolic process ,forebrain development , embryonic camera-type eye development , developmental induction , positive regulation of kinase activity , segmentation , regulation of phosphorylation , camera-type eye development , positive regulation of catalytic activity , regulation of MAP kinase activity , positive regulation of MAP kinase activity , regulation of kinase activity , positive regulation of molecular function , cell fate commitment , cell-cell signaling involved in cell fate specification , regulation of protein kinase activity , positive regulation of protein kinase activity , optic placode formation involved in camera-type eye , embryonic eye morphogenesis , embryonic organ morphogenesis , embryonic organ development , eye morphogenesis , camera-type eye morphogenesis , embryonic camera-type eye morphogenesis ,embryonic morphogenesis , regulation of phosphorus metabolic process , regulation of transferase activity , positive regulation of transferase activity ,

Endomembrane system. Cytoplasmic , membrane-bound.