ICK

Serine/threonine-protein kinase ICK ;
Intestinal cell kinase ;
hICK ;
Laryngeal cancer kinase 2 ;
LCK2 ;
MAK-related kinase ;
MRK ;

catalytic activity:ATP + a protein = ADP + a phosphoprotein. ,cofactor:Magnesium. ,disease:Defects in ICK are the cause of endocrine-cerebroosteodysplasia (ECO) [MIM:612651]. ECO is a previously unidentified neonatal lethal recessive disorder with multiple anomalies involving the endocrine , cerebral , and skeletal systems. ,function:May play a key role in the development of multiple organ systems and particularly in cardiac development. ,PTM:Autophosphorylated on serine and threonine residues. May play a role in enzyme activation. ,similarity:Belongs to the protein kinase superfamily. ,similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. ,similarity:Contains 1 protein kinase domain. ,subcellular location:Nuclear localization has been observed with a GFP-tagged construct in transfected HeLa cells (PubMed:12103360) . Cytosolic localization was shown in rat embryonic cardiomyocytes by immunostaining (PubMed:8570168) . ,tissue specificity:Expressed in heart , brain , placenta , pancreas , thymus , prostate , testis , ovary , small intestine and colon , with highest levels in placenta and testis. Not detected in spleen. Also expressed in many cancer cell lines. ,

protein amino acid phosphorylation , phosphorus metabolic process , phosphate metabolic process , intracellular signaling cascade , protein kinase cascade , phosphorylation ,

Nucleus . Cytoplasm , cytosol . Cell projection , cilium . Cytoplasm , cytoskeleton , cilium basal body . Also found at the ciliary tip (PubMed:24797473) . Nuclear localization has been observed with a GFP-tagged construct in transfected HeLa cells (PubMed:12103360 , PubMed:19185282) . .; [Isoform 2]: Cytoplasm . Predominant cytoplasmic localization has been observed with a N-terminally GFP-tagged construct. .