CAMK2B

alternative products:The variable region of the CAMK2B protein is encoded by at least 7 exons (V1 to V7) . Alternative splicing within this region gives rise to CAMK2B isoforms ,catalytic activity:ATP + a protein = ADP + a phosphoprotein. ,enzyme regulation:Autophosphorylation of CAMK2 plays an important role in the regulation of the kinase activity. ,function:CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses , it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity. ,similarity:Belongs to the protein kinase superfamily. ,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. ,similarity:Contains 1 protein kinase domain. ,subunit:CAMK2 is composed of four different chains: alpha , beta , gamma , and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. Interacts with SYNGAP1 and CAMK2N2 (By similarity) . Interacts with MPDZ. ,tissue specificity:Widely expressed. Expressed in adult and fetal brain. Expression is slightly lower in fetal brain. ,

G1/S transition of mitotic cell cycle , mitotic cell cycle , protein amino acid phosphorylation , phosphorus metabolic process , phosphate metabolic process , ion transport , cation transport , calcium ion transport , cell cycle , di- , tri-valent inorganic cation transport , phosphorylation , cell cycle process , cell cycle phase , metal ion transport , protein amino acid autophosphorylation , interphase , interphase of mitotic cell cycle ,

Cytoplasm , cytoskeleton . Cytoplasm , cytoskeleton , microtubule organizing center , centrosome . Sarcoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell junction , synapse . In slow-twitch muscle , evenly distributed between longitudinal SR and junctional SR.