VEGFR2 (Phospho Tyr951) Cell-Based Colorimetric ELISA Kit
-KA1674C
主要信息
Reactivity
Human, Mouse
Applications
ELISA
Conjugate/Modification
Phospho
详细信息
储存
2-8°C/6 months,Ship by ice bag
修饰
Phospho
检测方法
Colorimetric
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抗原&靶点信息
基因名称:
KDR FLK1 VEGFR2
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别名:
Vascular endothelial growth factor receptor 2 ;
VEGFR-2 ;
Fetal liver kinase 1 ;
FLK-1 ;
Kinase insert domain receptor ;
KDR ;
Protein-tyrosine kinase receptor flk-1 ;
CD antigen CD309 ;
VEGFR-2 ;
Fetal liver kinase 1 ;
FLK-1 ;
Kinase insert domain receptor ;
KDR ;
Protein-tyrosine kinase receptor flk-1 ;
CD antigen CD309 ;
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背景:
Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor , known as kinase insert domain receptor , is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation , survival , migration , tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors , including Rab GTPase , P2Y purine nucleotide receptor , integrin alphaVbeta3 , T-cell protein tyrosine phosphatase , etc.. Mutations of this gene are implicated in infantile capillary hemangiomas. [provided by RefSeq , May 2009] ,
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功能:
Catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. ,Function:Receptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. In case of HIV-1 infection , the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. ,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. ,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. ,similarity:Contains 1 protein kinase domain. ,similarity:Contains 7 Ig-like C2-type (immunoglobulin-like) domains. ,subunit:Interacts with MYOF (By similarity) . Interacts with SHB; upon VEGF activation. Interacts with HIV-1 Tat. ,
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细胞定位:
Cell junction . Endoplasmic reticulum . Cell membrane . Localized with RAP1A at cell-cell junctions (By similarity) . Colocalizes with ERN1 and XBP1 in the endoplasmic reticulum in endothelial cells in a vascular endothelial growth factor (VEGF) -dependent manner (PubMed:23529610) . .; [Isoform 1]: Cell membrane; Single-pass type I membrane protein. Cytoplasm. Nucleus. Cytoplasmic vesicle. Early endosome. Detected on caveolae-enriched lipid rafts at the cell surface. Is recycled from the plasma membrane to endosomes and back again. Phosphorylation triggered by VEGFA binding promotes internalization and subsequent degradation. VEGFA binding triggers internalization and translocation to the nucleus.; [Isoform 2]: Secreted .; [Isoform 3]: Secreted.
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信号通路
Cellular Processes >> Cellular community - eukaryotes >> Focal adhesion
Environmental Information Processing >> Signal transduction >> MAPK signaling pathway
Environmental Information Processing >> Signal transduction >> Ras signaling pathway
Environmental Information Processing >> Signal transduction >> Rap1 signaling pathway
Environmental Information Processing >> Signal transduction >> VEGF signaling pathway
Environmental Information Processing >> Signal transduction >> Calcium signaling pathway
Environmental Information Processing >> Signal transduction >> PI3K-Akt signaling pathway
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