Synapsin1 (Phospho Ser9) Cell-Based Colorimetric ELISA Kit
-KA1661C
主要信息
Reactivity
Human, Mouse, Rat
Applications
ELISA
Conjugate/Modification
Phospho
详细信息
储存
2-8°C/6 months,Ship by ice bag
修饰
Phospho
检测方法
Colorimetric
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抗原&靶点信息
基因名称:
SYN1
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别名:
Synapsin-1 ;
Brain protein 4.1 ;
Synapsin I ;
Brain protein 4.1 ;
Synapsin I ;
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背景:
disease:Defects in SYN1 are a cause of epilepsy X-linked with variable learning disabilities and behavior disorders [MIM:300491]. XELBD is characterized by variable combinations of epilepsy , learning difficulties , macrocephaly , and aggressive behavior. ,function:Neuronal phosphoprotein that coats synaptic vesicles , binds to the cytoskeleton , and is believed to function in the regulation of neurotransmitter release. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level. ,PTM:Substrate of at least four different protein kinases. It is probable that phosphorylation plays a role in the regulation of synapsin-1 in the nerve terminal. Phosphorylated upon DNA damage , probably by ATM or ATR. ,similarity:Belongs to the synapsin family. ,subunit:Homodimer. Interacts with CAPON. Forms a ternary complex with NOS1. Isoform Ib interacts with PRNP. ,
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功能:
regulation of neurotransmitter levels , generation of a signal involved in cell-cell signaling , neurotransmitter transport ,cell-cell signaling , synaptic transmission , neurotransmitter secretion , transmission of nerve impulse , secretion by cell ,secretion , neurological system process ,
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细胞定位:
Cell junction , synapse. Golgi apparatus .
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