SRC SRC1

SRC ;
SRC1 ;
Proto-oncogene tyrosine-protein kinase Src ;
Proto-oncogene c-Src ;
pp60c-src ;
p60-Src

catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. ,PTM:Phosphorylated on Tyr-530 by c-Src kinase (CSK) . The phosphorylated form is termed pp60c-src. The phosphorylated tail interacts with the SH2 domain thereby repressing kinase activity. ,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily. ,similarity:Contains 1 protein kinase domain. ,similarity:Contains 1 SH2 domain. ,similarity:Contains 1 SH3 domain. ,subunit:Interacts with DDEF1/ASAP1; via the SH3 domain. Interacts with CCPG1 (By similarity) . Interacts with CDCP1 , PELP1 , TGFB1I1 and TOM1L2. Interacts with the cytoplasmic domain of MUC1 , phosphorylates it and increases binding of MUC1 with beta-catenin. Interacts with RALGPS1; via the SH3 domain. Interacts with HEV ORF3 protein; via the SH3 domain. ,

response to acid , protein complex assembly , protein amino acid phosphorylation , phosphorus metabolic process ,phosphate metabolic process , cell motion , cell adhesion , cell surface receptor linked signal transduction , enzyme linked receptor protein signaling pathway , transmembrane receptor protein tyrosine kinase signaling pathway , signal complex assembly , epidermal growth factor receptor signaling pathway , intracellular signaling cascade , protein kinase cascade , small GTPase mediated signal transduction , Ras protein signal transduction , cell proliferation , response to endogenous stimulus , response to hormone stimulus , positive regulation of signal transduction , response to organic substance , positive regulation of cell communication , regulation of cell death , positive regulation of cell death , vesicle-mediated transport , phosphorylation , cell-cell adhesion , cell migration , peptidyl-tyrosine phosphorylation , peptidyl-tyrosine modification , biological adhesion , regulation of cell adhesion , forebrain development , response to corticosteroid stimulus , response to cytokine stimulus , cellular macromolecular complex subunit organization , cellular macromolecular complex assembly , regulation of apoptosis , positive regulation of apoptosis , regulation of programmed cell death , positive regulation of programmed cell death , cellular protein complex assembly ,macromolecular complex subunit organization , transcytosis , positive regulation of cell adhesion , regulation of insulin receptor signaling pathway , positive regulation of insulin receptor signaling pathway , platelet-derived growth factor receptor signaling pathway , nerve growth factor receptor signaling pathway , response to steroid hormone stimulus ,positive regulation of response to stimulus , cell motility , response to mineralocorticoid stimulus , localization of cell ,macromolecular complex assembly , protein complex biogenesis , response to interleukin-1 ,

Cell membrane ; Lipid-anchor . Mitochondrion inner membrane . Nucleus . Cytoplasm , cytoskeleton . Cytoplasm , perinuclear region . Cell junction , focal adhesion . Localizes to focal adhesion sites following integrin engagement (PubMed:22801373) . Localization to focal adhesion sites requires myristoylation and the SH3 domain (PubMed:7525268) . Colocalizes with PDLIM4 at the perinuclear region , but not at focal adhesions (PubMed:19307596) . .