MAP2K4 JNKK1 MEK4 MKK4 PRKMK4 SEK1 SERK1 SKK1

Dual specificity mitogen-activated protein kinase kinase 4 ;
MAP kinase kinase 4 ;
MAPKK 4 ;
JNK-activating kinase 1 ;
MAPK/ERK kinase 4 ;
MEK 4 ;
SAPK/ERK kinase 1 ;
SEK1 ;
Stress-activated protein kinase kinase 1 ;
SAPK kinase 1 ;
SAPKK-1 ;
SAPKK1 ;
c-Jun N-terminal kinase kinase 1 ;
JNKK ;

catalytic activity:ATP + a protein = ADP + a phosphoprotein. ,function:Dual specificity kinase that activates the JUN kinases MAPK8 (JNK1) and MAPK9 (JNK2) as well as MAPK14 (p38) but not MAPK1 (ERK2) or MAPK3 (ERK1) . ,PTM:Activated by phosphorylation on Ser/Thr by MAP kinase kinase kinases. ,similarity:Belongs to the protein kinase superfamily. ,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. ,similarity:Contains 1 protein kinase domain. ,subunit:Interacts with SPAG9. ,tissue specificity:Abundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues. ,

MAPKKK cascade , protein amino acid phosphorylation , phosphorus metabolic process , phosphate metabolic process ,intracellular signaling cascade , protein kinase cascade , JNK cascade , phosphorylation , stress-activated protein kinase signaling pathway , cellular response to stress ,

Cytoplasm . Nucleus .