REL

REL ;
Proto-oncogene c-Rel

function:Proto-oncogene that may play a role in differentiation and lymphopoiesis. NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation , immunity , differentiation , cell growth , tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65 , RELB , NFKB1/p105 , NFKB1/p50 , REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors , respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway , I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators , subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The NF-kappa-B heterodimer RELA/p65-c-Rel is a transcriptional activator. ,similarity:Contains 1 RHD (Rel-like) domain. ,subunit:Component of the NF-kappa-B p65-c-Rel complex. Component of the NF-kappa-B p50-c-Rel complex. Component of the NF-kappa-B p52-c-Rel complex. Homodimer; component of the NF-kappa-B c-Rel-c-Rel complex (By similarity) . Interacts with NKIRAS1. Interacts with NFKBIB (By similarity) . Interacts with NFKBIE. ,

cytokine production , regulation of cytokine production , transcription , regulation of transcription , DNA-dependent ,positive regulation of biosynthetic process , positive regulation of signal transduction , positive regulation of macromolecule biosynthetic process , positive regulation of macromolecule metabolic process , regulation of protein kinase cascade , positive regulation of gene expression , positive regulation of cell communication , positive regulation of protein kinase cascade , positive regulation of cellular biosynthetic process , regulation of interleukin-12 production ,regulation of cytokine biosynthetic process , positive regulation of cytokine biosynthetic process , regulation of I-kappaB kinase/NF-kappaB cascade , positive regulation of I-kappaB kinase/NF-kappaB cascade , regulation of interleukin-12 biosynthetic process , positive regulation of interleukin-12 biosynthetic process , regulation of transcription , positive regulation of transcription , DNA-dependent , positive regulation of nucleobase , nucleoside , nucleotide and nucleic acid metabolic process , positive regulation of transcription , positive regulation of nitrogen compound metabolic process ,regulation of RNA metabolic process , positive regulation of RNA metabolic process ,

Nucleus .