MAP2K6

Dual specificity mitogen-activated protein kinase kinase 6 ;
MAP kinase kinase 6 ;
MAPKK 6 ;
MAPK/ERK kinase 6 ;
MEK 6 ;
Stress-activated protein kinase kinase 3 ;
SAPK kinase 3 ;
SAPKK-3 ;
SAPKK3 ;

catalytic activity:ATP + a protein = ADP + a phosphoprotein. ,enzyme regulation:Probably activated by dual phosphorylation on Ser-207 and Thr-211. ,function:Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in MAP kinase p38 exclusively. ,induction:Strongly activated by UV , anisomycin , and osmotic shock but not by phorbol esters , NGF or EGF. ,PTM:Acetylation of Ser-207 and Thr-211 by Yersinia yopJ prevents phosphorylation and activation , thus blocking the MAPK signaling pathway. ,PTM:Weakly autophosphorylated. ,similarity:Belongs to the protein kinase superfamily. ,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. ,similarity:Contains 1 protein kinase domain. ,subunit:Interacts with Yersinia yopJ. ,tissue specificity:Isoform 2 is only expressed in skeletal muscle. Isoform 1 , on the other hand , is found in skeletal muscle , heart , and in lesser extent in liver or pancreas. ,

MAPKKK cascade , activation of MAPK activity , muscle system process , circulatory system process , heart process ,protein amino acid phosphorylation , phosphorus metabolic process , phosphate metabolic process , muscle contraction ,striated muscle contraction , response to DNA damage stimulus , DNA damage induced protein phosphorylation , cell cycle , cell cycle arrest , intracellular signaling cascade , protein kinase cascade , blood circulation , regulation of cell death , positive regulation of cell death , phosphorylation , regulation of phosphate metabolic process , cell cycle process , cellular response to stress , positive regulation of kinase activity , regulation of phosphorylation , response to drug , regulation of apoptosis , positive regulation of apoptosis , regulation of programmed cell death , positive regulation of programmed cell death , positive regulation of catalytic activity , regulation of MAP kinase activity , positive regulation of MAP kinase activity , regulation of kinase activity , positive regulation of molecular function , regulation of protein kinase activity , positive regulation of protein kinase activity , regulation of phosphorus metabolic process ,regulation of transferase activity , positive regulation of transferase activity , heart contraction , cardiac muscle contraction ,

Nucleus . Cytoplasm . Cytoplasm , cytoskeleton . Binds to microtubules.