MAP2K3

Dual specificity mitogen-activated protein kinase kinase 3 ;
MAP kinase kinase 3 ;
MAPKK 3 ;
MAPK/ERK kinase 3 ;
MEK 3 ;
Stress-activated protein kinase kinase 2 ;
SAPK kinase 2 ;
SAPKK-2 ;
SAPKK2 ;

catalytic activity:ATP + a protein = ADP + a phosphoprotein. ,disease:Defects in MAP2K3 may be involved in colon cancer. ,enzyme regulation:Activated by dual phosphorylation on Ser-218 and Thr-222. ,function:Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38. ,PTM:Autophosphorylated. ,PTM:Phosphorylation on Ser-218 and Thr-222 by MAP kinase kinase kinases regulates positively the kinase activity. ,PTM:Yersinia yopJ may acetylate Ser/Thr residues , preventing phosphorylation and activation , thus blocking the MAPK signaling pathway. ,similarity:Belongs to the protein kinase superfamily. ,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. ,similarity:Contains 1 protein kinase domain. ,subunit:Binds to DYRK1B/MIRK and increases its kinase activity. Part of a complex with MAP3K3 , RAC1 and CCM2. Interacts with Yersinia yopJ. ,tissue specificity:Abundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues. ,

MAPKKK cascade , activation of MAPK activity , regulation of cytokine production , muscle system process , circulatory system process , heart process , regulation of transcription , DNA-dependent , protein amino acid phosphorylation ,phosphorus metabolic process , phosphate metabolic process , muscle contraction , striated muscle contraction , defense response , inflammatory response , intracellular signaling cascade , protein kinase cascade , blood circulation , response to wounding , positive regulation of biosynthetic process , positive regulation of macromolecule biosynthetic process ,positive regulation of macromolecule metabolic process , positive regulation of gene expression , phosphorylation ,regulation of phosphate metabolic process , positive regulation of cellular biosynthetic process , positive regulation of kinase activity , regulation of cytokine biosynthetic process , regulation of phosphorylation , positive regulation of catalytic activity , regulation of MAP kinase activity , positive regulation of MAP kinase activity , regulation of kinase activity , positive regulation of molecular function , regulation of transcription , regulation of protein kinase activity ,positive regulation of protein kinase activity , positive regulation of transcription , DNA-dependent , positive regulation of nucleobase , nucleoside , nucleotide and nucleic acid metabolic process , positive regulation of transcription , positive regulation of nitrogen compound metabolic process , regulation of phosphorus metabolic process , regulation of RNA metabolic process , positive regulation of RNA metabolic process , regulation of transferase activity , positive regulation of transferase activity , heart contraction , cardiac muscle contraction ,