详细信息
推荐稀释比
Reconstitute in sterile water for a stock solution
组成
Supplied as solution form in PBS, pH7.5 ./ Lyophilized from PBS, pH7.5 .
来源
Baculovirus-Insect cells
纯度
>90% as determined by SDS-PAGE
储存
Use a manual defrost freezer and avoid repeated freeze thaw cycles.
Store at 2 to 8 °C for one week .
Store at -20 to -80 °C for twelve months from the date of receipt.
抗原&靶点信息
序列:
A DNA sequence encoding the Human CLDN1 (Met1-Val211）was fused with the C-terminal His Tag
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别名:
Senescence-associated epithelial membrane protein,CLD1, SEMP1
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背景:
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome. [provided by RefSeq, Jul 2008]
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细胞定位:
Cell junction, tight junction . Cell membrane ; Multi-pass membrane protein . Basolateral cell membrane . Associates with CD81 and the CLDN1-CD81 complex localizes to the basolateral cell membrane. .
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组织表达:
Strongly expressed in liver and kidney. Expressed in heart, brain, spleen, lung and testis.
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信号通路
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