LIMK2

LIM domain kinase 2 ;
LIMK-2 ;

catalytic activity:ATP + a protein = ADP + a phosphoprotein. ,function:Displays serine/threonine-specific phosphorylation of myelin basic protein and histone (MBP) in vitro. ,PTM:Phosphorylated on serine and/or threonine residues by ROCK1. ,similarity:Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. ,similarity:Contains 1 PDZ (DHR) domain. ,similarity:Contains 1 protein kinase domain. ,similarity:Contains 2 LIM zinc-binding domains. ,subcellular location:Isoform LIMK2a is distributed in the cytoplasm and the nucleus. ,subcellular location:Isoform LIMK2b occurs mainly in the cytoplasm and is scarcely translocated to the nucleus. ,subunit:Binds ROCK1 and LKAP. Interacts with PARD3. Interacts with NISCH. ,tissue specificity:Highest expression in the placenta; moderate level in liver , lung , kidney , and pancreas. LIMK2a is found to be more abundant then LIMK2b in liver , colon , stomach , and spleen , while in brain , kidney , and placenta LIMK2b is the dominant form. In adult lung , both LIMK2a and LIMK2b is nearly equally observed. ,

protein amino acid phosphorylation , phosphorus metabolic process , phosphate metabolic process , gamete generation ,spermatogenesis , phosphorylation , regulation of phosphate metabolic process , sexual reproduction , multicellular organism reproduction , regulation of phosphorylation , male gamete generation , reproductive process in a multicellular organism , regulation of phosphorus metabolic process ,

Cytoplasm , cytoskeleton , spindle . Cytoplasm , cytoskeleton , microtubule organizing center , centrosome .; [Isoform LIMK2a]: Cytoplasm . Nucleus .; [Isoform LIMK2b]: Cytoplasm . Cytoplasm , perinuclear region . Nucleus . Mainly present in the cytoplasm and is scarcely translocated to the nucleus. .