KIT SCFR

Mast/stem cell growth factor receptor Kit ;
SCFR ;
Piebald trait protein ;
PBT ;
Proto-oncogene c-Kit ;
Tyrosine-protein kinase Kit ;
p145 c-kit ;
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog ;
CD antigen CD117 ;

catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. ,disease:Defects in KIT are a cause of gastrointestinal stromal tumor (GIST) [MIM:606764]. ,disease:Defects in KIT are a cause of piebaldism [MIM:172800]. Piebaldism is an autosomal dominant genetic developmental abnormality of pigmentation characterized by congenital patches of white skin and hair that lack melanocytes. ,disease:Defects in KIT have been associated with testicular tumors [MIM:273300]. It includes germ cell tumor (GCT) or testicular germ cell tumor (TGCT) . ,function:This is the receptor for stem cell factor (mast cell growth factor) . It has a tyrosine-protein kinase activity. Binding of the ligands leads to the autophosphorylation of KIT and its association with substrates such as phosphatidylinositol 3-kinase (Pi3K) . ,online information:CD117 entry ,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. ,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. ,similarity:Contains 1 protein kinase domain. ,similarity:Contains 5 Ig-like C2-type (immunoglobulin-like) domains. ,subunit:Interacts with APS. Interacts with MPDZ (via the tenth PDZ domain) . Interacts with PTPRU. ,

hemopoietic progenitor cell differentiation , myeloid progenitor cell differentiation , lymphoid progenitor cell differentiation , immune system development , leukocyte differentiation , myeloid leukocyte differentiation , reproductive developmental process , protein amino acid phosphorylation , membrane lipid metabolic process , glycolipid metabolic process , sphingolipid metabolic process , glycosphingolipid metabolic process , phosphorus metabolic process ,phosphate metabolic process , cell motion , cell surface receptor linked signal transduction , enzyme linked receptor protein signaling pathway , transmembrane receptor protein tyrosine kinase signaling pathway , intracellular signaling cascade , protein kinase cascade , gamete generation , germ cell development , spermatogenesis , spermatid development , behavior , learning or memory , learning , visual behavior , cell death , cell proliferation , positive regulation of cell proliferation , germ cell migration , visual learning , regulation of Notch signaling pathway , response to radiation ,response to light stimulus , response to abiotic stimulus , positive regulation of signal transduction , positive regulation of macromolecule metabolic process , developmental programmed cell death , positive regulation of gene expression ,positive regulation of cell communication , positive regulation of cell development , regulation of cell death , programmed cell death , death , phosphorylation , cell migration , stem cell division , peptidyl-tyrosine phosphorylation , peptidyl-tyrosine modification , regulation of phosphate metabolic process , cytokine-mediated signaling pathway , stem cell maintenance , sexual reproduction , hemopoiesis , myeloid cell differentiation , regulation of cell migration , positive regulation of cell migration , regulation of pseudopodium assembly , positive regulation of pseudopodium assembly ,regulation of cell projection organization , positive regulation of cell projection organization , regulation of neurological system process , multicellular organism reproduction , positive regulation of kinase activity , somatic stem cell maintenance , germ cell programmed cell death , regulation of locomotion , positive regulation of locomotion , regulation of cell proliferation , regulation of phosphorylation , regulation of programmed cell death , negative regulation of programmed cell death , positive regulation of catalytic activity , regulation of MAP kinase activity , positive regulation of MAP kinase activity , pigmentation , regulation of kinase activity , regulation of system process , regulation of cellular component biogenesis , positive regulation of molecular function , negative regulation of cell differentiation , positive regulation of cell differentiation , positive regulation of Notch signaling pathway , regulation of protein kinase activity ,positive regulation of protein kinase activity , protein amino acid autophosphorylation , pigmentation during development , regulation of pigmentation during development , somatic stem cell division , regulation of synaptic plasticity , regulation of neuronal synaptic plasticity , regulation of long-term neuronal synaptic plasticity , positive regulation of long-term neuronal synaptic plasticity , male gamete generation , spermatid differentiation , hemopoietic or lymphoid organ development , reproductive process in a multicellular organism , reproductive cellular process , stem cell differentiation , stem cell development , cell motility , epithelial cell proliferation , regulation of neurogenesis , positive regulation of neurogenesis , regulation of synaptic transmission , neurological system process , cognition , positive regulation of developmental process , positive regulation of cellular component organization , regulation of phosphorus metabolic process , regulation of cell motion , positive regulation of cell motion , cell division , regulation of transferase activity , positive regulation of transferase activity , localization of cell , regulation of nervous system development ,regulation of transmission of nerve impulse , regulation of cell development , regulation of cell projection assembly ,negative regulation of cell death ,

[Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Cell membrane; Single-pass type I membrane protein.; [Isoform 3]: Cytoplasm . Detected in the cytoplasm of spermatozoa , especially in the equatorial and subacrosomal region of the sperm head. .