RELA

Transcription factor p65 ;
Nuclear factor NF-kappa-B p65 subunit ;
Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3 ;

NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor , NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL , RELA , or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene , RELA. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq , Sep 2011] ,

response to reactive oxygen species , response to acid , regulation of cytokine production , liver development , hair follicle development , activation of innate immune response , pattern recognition receptor signaling pathway , response to molecule of bacterial origin , immune effector process , activation of immune response , positive regulation of immune system process , immune response-activating signal transduction , innate immune response-activating signal transduction , immune response-regulating signal transduction , transcription , regulation of transcription , DNA-dependent , regulation of transcription from RNA polymerase II promoter , proteolysis , anti-apoptosis , defense response , inflammatory response , immune response , cellular defense response , response to oxidative stress ,ectoderm development , aging , response to nutrient , positive regulation of cell proliferation , epidermis development ,macromolecule catabolic process , response to radiation , response to UV , response to light stimulus , response to wounding , response to mechanical stimulus , response to virus , response to bacterium , response to abiotic stimulus ,response to endogenous stimulus , response to hormone stimulus , positive regulation of biosynthetic process ,regulation of catabolic process , negative regulation of catabolic process , positive regulation of signal transduction ,negative regulation of signal transduction , response to extracellular stimulus , response to organic substance ,response to inorganic substance , response to UV-B , response to organic nitrogen , positive regulation of macromolecule biosynthetic process , positive regulation of macromolecule metabolic process , negative regulation of macromolecule metabolic process , regulation of protein kinase cascade , positive regulation of gene expression ,positive regulation of cell communication , negative regulation of cell communication , positive regulation of cell development , positive regulation of protein kinase cascade , regulation of cell death , regulation of gliogenesis , positive regulation of gliogenesis , regulation of Schwann cell differentiation , positive regulation of Schwann cell differentiation ,response to organic cyclic substance , response to isoquinoline alkaloid , response to amine stimulus , cytokine-mediated signaling pathway , molting cycle process , hair cycle process , protein catabolic process , membrane protein intracellular domain proteolysis , positive regulation of cellular biosynthetic process , positive regulation of defense response , response to nutrient levels , regulation of chondrocyte differentiation , positive regulation of chondrocyte differentiation , response to lipopolysaccharide , response to progesterone stimulus , regulation of interleukin-12 production , response to insulin stimulus , response to vitamin , response to cobalamin , membrane protein proteolysis ,response to cytokine stimulus , regulation of cytokine biosynthetic process , positive regulation of cytokine biosynthetic process , regulation of cell proliferation , regulation of protein catabolic process , negative regulation of protein catabolic process , molting cycle , response to drug , response to hydrogen peroxide , hair cycle , regulation of apoptosis , negative regulation of apoptosis , regulation of programmed cell death , negative regulation of programmed cell death ,regulation of I-kappaB kinase/NF-kappaB cascade , positive regulation of I-kappaB kinase/NF-kappaB cascade ,response to amino acid stimulus , response to morphine , response to alkaloid , positive regulation of DNA binding ,response to peptide hormone stimulus , positive regulation of molecular function , cellular protein catabolic process ,cellular macromolecule catabolic process , regulation of interleukin-12 biosynthetic process , positive regulation of interleukin-12 biosynthetic process , regulation of innate immune response , positive regulation of innate immune response , regulation of transcription , positive regulation of cell differentiation , regulation of glial cell differentiation ,positive regulation of glial cell differentiation , positive regulation of transcription , DNA-dependent , positive regulation of nucleobase , nucleoside , nucleotide and nucleic acid metabolic process , positive regulation of transcription , positive regulation of transcription from RNA polymerase II promoter , regulation of insulin receptor signaling pathway , negative regulation of insulin receptor signaling pathway , response to steroid hormone stimulus , positive regulation of response to stimulus , negative regulation of response to stimulus , regulation of neurogenesis , positive regulation of neurogenesis , positive regulation of immune response , regulation of transcription factor activity , positive regulation of transcription factor activity , positive regulation of NF-kappaB transcription factor activity , positive regulation of developmental process , regulation of binding , positive regulation of binding , regulation of DNA binding , positive regulation of nitrogen compound metabolic process , negative regulation of protein metabolic process , regulation of RNA metabolic process , positive regulation of RNA metabolic process , response to cAMP , proteolysis involved in cellular protein catabolic process , defense response to virus , regulation of nervous system development , regulation of cell development , negative regulation of cell death , nucleotide-binding oligomerization domain containing signaling pathway , nucleotide-binding oligomerization domain containing 2 signaling pathway , response to interleukin-1 ,

Nucleus . Cytoplasm . Nuclear , but also found in the cytoplasm in an inactive form complexed to an inhibitor (I-kappa-B) (PubMed:1493333) . Colocalized with DDX1 in the nucleus upon TNF-alpha induction (PubMed:19058135) . Colocalizes with GFI1 in the nucleus after LPS stimulation (PubMed:20547752) . Translocation to the nucleus is impaired in L.monocytogenes infection (PubMed:20855622) . .