JAK1

Tyrosine-protein kinase JAK1 ;
Janus kinase 1 ;
JAK-1 ;

catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. ,domain:Possesses two phosphotransferase domains. The second one probably contains the catalytic domain (By similarity) , while the presence of slight differences suggest a different role for domain 1. ,domain:The FERM domain mediates interaction with JAKMIP1. ,function:Tyrosine kinase of the non-receptor type , involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL) -2 receptor. ,sequence caution:Translation N-terminally extended. ,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily. ,similarity:Contains 1 FERM domain. ,similarity:Contains 1 protein kinase domain. ,similarity:Contains 1 SH2 domain. ,subcellular location:Wholly intracellular , possibly membrane associated. ,subunit:Interacts with IL31RA , JAKMIP1 and SHB. ,tissue specificity:Expressed at higher levels in primary colon tumors than in normal colon tissue. The expression level in metastatic colon tumors is comparable to the expression level in normal colon tissue. ,

protein amino acid phosphorylation , phosphorus metabolic process , phosphate metabolic process , cell surface receptor linked signal transduction , enzyme linked receptor protein signaling pathway , intracellular signaling cascade ,protein kinase cascade , phosphorylation , peptidyl-tyrosine phosphorylation , peptidyl-tyrosine modification , cytokine-mediated signaling pathway , response to antibiotic ,

Endomembrane system; Peripheral membrane protein. Wholly intracellular , possibly membrane associated.