HNF4A HNF4 NR2A1 TCF14

HNF4A ;
HNF4 ;
NR2A1 ;
TCF14 ;
Hepatocyte nuclear factor 4-alpha ;
HNF-4-alpha ;
Nuclear receptor subfamily 2 group A member 1 ;
Transcription factor 14 ;
TCF-14 ;
Transcription factor HNF-4

alternative products:Additional isoforms seem to exist ,disease:Defects in HNF4A are the cause of maturity onset diabetes of the young type 1 (MODY1) [MIM:125850]; also shortened MODY-1. MODY [MIM:606391] is a form of diabetes that is characterized by an autosomal dominant mode of inheritance , onset in childhood or early adulthood (usually before 25 years of age) and a primary defect in insulin secretion. The clinical phenotype of MODY1 is characterized by severe insulin secretory defects , and by major hyperglycemia associated with microvascular complications. ,function:Transcriptionally controlled transcription factor. Binds to DNA sites required for the transcription of alpha 1-antitrypsin , apolipoprotein CIII , transthyretin genes and HNF1-alpha. May be essential for development of the liver , kidney and intestine. ,miscellaneous:Binds fatty acids. ,online information:Hepatocyte nuclear factors entry ,PTM:Phosphorylated on tyrosine residue (s) ; phosphorylation is important for its DNA-binding activity. Phosphorylation may directly or indirectly play a regulatory role in the subnuclear distribution. ,similarity:Belongs to the nuclear hormone receptor family. ,similarity:Belongs to the nuclear hormone receptor family. NR2 subfamily. ,similarity:Contains 1 nuclear receptor DNA-binding domain. ,subunit:Homodimerization is required for HNF4-alpha to bind to its recognition site. ,

regulation of cell growth , regulation of protein amino acid phosphorylation , negative regulation of protein amino acid phosphorylation , regulation of carbohydrate metabolic process , regulation of gluconeogenesis , transcription ,regulation of transcription , DNA-dependent , regulation of transcription from RNA polymerase II promoter , ornithine metabolic process , acyl-CoA metabolic process , coenzyme metabolic process , xenobiotic metabolic process ,establishment of tissue polarity , regulation of mitotic cell cycle , blood coagulation , hemostasis , negative regulation of cell proliferation , regulation of cell size , response to xenobiotic stimulus , response to wounding , response to carbohydrate stimulus , response to hexose stimulus , response to glucose stimulus , positive regulation of biosynthetic process , negative regulation of signal transduction , response to organic substance , regulation of specific transcription from RNA polymerase II promoter , positive regulation of specific transcription from RNA polymerase II promoter ,positive regulation of macromolecule biosynthetic process , negative regulation of phosphorus metabolic process ,regulation of cellular ketone metabolic process , positive regulation of macromolecule metabolic process , negative regulation of macromolecule metabolic process , regulation of protein kinase cascade , positive regulation of gene expression , negative regulation of cell communication , regulation of cellular carbohydrate metabolic process , positive regulation of cellular carbohydrate metabolic process , negative regulation of protein kinase cascade , regulation of glucose metabolic process , positive regulation of glucose metabolic process , regulation of lipid metabolic process ,regulation of fatty acid metabolic process , regulation of phosphate metabolic process , negative regulation of cell growth , positive regulation of cellular biosynthetic process , regulation of protein modification process , negative regulation of protein modification process , regulation of cellular protein metabolic process , negative regulation of cellular protein metabolic process , regulation of intracellular transport , negative regulation of intracellular transport ,regulation of cellular component size , regulation of gene-specific transcription , regulation of protein localization ,regulation of intracellular protein transport , regulation of protein import into nucleus , translocation , negative regulation of protein import into nucleus , translocation , response to monosaccharide stimulus , cell junction organization , regulation of growth , wound healing , regulation of cell proliferation , regulation of fatty acid biosynthetic process , regulation of protein import into nucleus , regulation of phosphorylation , negative regulation of phosphorylation , regulation of tyrosine phosphorylation of STAT protein , regulation of tyrosine phosphorylation of Stat5 protein , negative regulation of tyrosine phosphorylation of Stat5 protein , negative regulation of tyrosine phosphorylation of STAT protein , homeostatic process , positive regulation of gene-specific transcription , regulation of carbohydrate biosynthetic process , negative regulation of DNA binding , negative regulation of transcription factor activity , negative regulation of molecular function , cell-cell junction organization , regulation of transcription , positive regulation of gluconeogenesis , positive regulation of fatty acid biosynthetic process , negative regulation of cell cycle ,negative regulation of cell size , positive regulation of lipid metabolic process , positive regulation of transcription , DNA-dependent , positive regulation of carbohydrate metabolic process , positive regulation of fatty acid metabolic process ,negative regulation of growth , negative regulation of mitotic cell cycle , positive regulation of nucleobase , nucleoside , nucleotide and nucleic acid metabolic process , negative regulation of phosphate metabolic process , positive regulation of transcription , positive regulation of transcription from RNA polymerase II promoter , regulation of JAK-STAT cascade ,negative regulation of JAK-STAT cascade , regulation of nucleocytoplasmic transport , positive regulation of lipid biosynthetic process , regulation of lipid biosynthetic process , chemical homeostasis , regulation of peptidyl-tyrosine phosphorylation , negative regulation of peptidyl-tyrosine phosphorylation , coagulation , regulation of body fluid levels ,negative regulation of transport , regulation of transcription factor activity , regulation of binding , negative regulation of binding , regulation of DNA binding , positive regulation of nitrogen compound metabolic process , regulation of phosphorus metabolic process , cofactor metabolic process , regulation of protein transport , negative regulation of protein transport , negative regulation of protein metabolic process , regulation of RNA metabolic process , positive regulation of RNA metabolic process , regulation of cell cycle , lipid homeostasis , regulation of cellular localization ,regulation of growth hormone receptor signaling pathway , regulation of establishment of protein localization ,

Nucleus.