HDAC5

Histone deacetylase 5 ;
HD5 ;
Antigen NY-CO-9 ;

catalytic activity:Hydrolysis of an N (6) -acetyl-lysine residue of a histone to yield a deacetylated histone. ,domain:The nuclear export sequence mediates the shuttling between the nucleus and the cytoplasm. ,function:Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A , H2B , H3 and H4) . Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation , cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer MEF2C. During muscle differentiation , it shuttles into the cytoplasm , allowing the expression of myocyte enhancer factors. ,PTM:Phosphorylated by CaMK at Ser-259 and Ser-498. The phosphorylation is required for the export to the cytoplasm. ,PTM:Ubiquitinated. Polyubiquitination however does not lead to its degradation. ,similarity:Belongs to the histone deacetylase family. Type 2 subfamily. ,subcellular location:Shuttles between the nucleus and the cytoplasm. In muscle cells , it shuttles into the cytoplasm during myocyte differentiation. The export to cytoplasm depends on the interaction with a 14-3-3 chaperone protein and is due to its phosphorylation at Ser-259 and Ser-498 by CaMK. ,subunit:Interacts with AHRR (By similarity) . Interacts with BCOR , HDAC7 , HDAC9 , CTBP1 , MEF2C , NCOR2 , NRIP1 , PHB2 and a 14-3-3 chaperone protein. Interacts with KDM5B. ,tissue specificity:Ubiquitous. ,

negative regulation of transcription from RNA polymerase II promoter , cell activation , immune system development ,leukocyte differentiation , muscle system process , chromatin organization , chromatin remodeling , chromatin silencing ,transcription , regulation of transcription , DNA-dependent , regulation of transcription from RNA polymerase II promoter ,protein amino acid deacetylation , defense response , inflammatory response , heart development , response to wounding , response to endogenous stimulus , response to hormone stimulus , negative regulation of biosynthetic process , positive regulation of biosynthetic process , response to organic substance , regulation of specific transcription from RNA polymerase II promoter , positive regulation of specific transcription from RNA polymerase II promoter ,negative regulation of specific transcription from RNA polymerase II promoter , positive regulation of macromolecule biosynthetic process , negative regulation of macromolecule biosynthetic process , regulation of endothelial cell migration , negative regulation of endothelial cell migration , positive regulation of macromolecule metabolic process ,negative regulation of macromolecule metabolic process , positive regulation of gene expression , negative regulation of gene expression , regulation of myotube differentiation , negative regulation of myotube differentiation , cardiac muscle adaptation , striated muscle adaptation , muscle hypertrophy , striated muscle hypertrophy , cardiac muscle hypertrophy , regulation of striated muscle tissue development , gene silencing , negative regulation of transcription ,negative regulation of angiogenesis , chromatin modification , covalent chromatin modification , histone modification ,histone deacetylation , hemopoiesis , lymphocyte differentiation , B cell differentiation , regulation of cell migration ,negative regulation of cell migration , negative regulation of cellular biosynthetic process , positive regulation of cellular biosynthetic process , negative regulation of gene-specific transcription , regulation of gene-specific transcription ,response to insulin stimulus , cellular response to insulin stimulus , cellular response to hormone stimulus , regulation of locomotion , negative regulation of locomotion , regulation of gene expression , epigenetic , B cell activation , positive regulation of gene-specific transcription , positive regulation of DNA binding , regulation of protein binding , response to peptide hormone stimulus , muscle adaptation , regulation of blood vessel endothelial cell migration , negative regulation of blood vessel endothelial cell migration , positive regulation of molecular function , leukocyte activation ,regulation of transcription , negative regulation of cell differentiation , regulation of angiogenesis , negative regulation of gene expression , epigenetic , negative regulation of transcription , DNA-dependent , positive regulation of transcription , DNA-dependent , negative regulation of nucleobase , nucleoside , nucleotide and nucleic acid metabolic process , positive regulation of nucleobase , nucleoside , nucleotide and nucleic acid metabolic process , positive regulation of transcription , positive regulation of transcription from RNA polymerase II promoter , lymphocyte activation , hemopoietic or lymphoid organ development , regulation of muscle development , regulation of skeletal muscle tissue development , regulation of skeletal muscle fiber development , regulation of transcription factor activity ,positive regulation of transcription factor activity , regulation of binding , positive regulation of binding , regulation of DNA binding , regulation of muscle cell differentiation , negative regulation of muscle cell differentiation , regulation of striated muscle cell differentiation , negative regulation of striated muscle cell differentiation , negative regulation of nitrogen compound metabolic process , positive regulation of nitrogen compound metabolic process , regulation of RNA metabolic process , negative regulation of RNA metabolic process , positive regulation of RNA metabolic process ,regulation of cell motion , negative regulation of cell motion , chromosome organization , regulation of cell development ,

Nucleus. Cytoplasm. Shuttles between the nucleus and the cytoplasm. In muscle cells , it shuttles into the cytoplasm during myocyte differentiation. The export to cytoplasm depends on the interaction with a 14-3-3 chaperone protein and is due to its phosphorylation at Ser-259 and Ser-498 by AMPK , CaMK1 and SIK1.