HDAC2

Histone deacetylase 2 ;
HD2 ;

catalytic activity:Hydrolysis of an N (6) -acetyl-lysine residue of a histone to yield a deacetylated histone. ,function:Forms transcriptional repressor complexes by associating with MAD , SIN3 , YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed of DNMT1 , DMAP1 , PCNA , CAF1. ,function:Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A , H2B , H3 and H4) . Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation , cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. ,sequence caution:Intron retention. ,similarity:Belongs to the histone deacetylase family. Type 1 subfamily. ,subunit:Interacts with the non-histone region of H2AFY (By similarity) . Part of the core histone deacetylase (HDAC) complex composed of HDAC1 , HDAC2 , RBBP4 and RBBP7. The core complex associates with MTA2 , MBD3 , MTA1L1 , CHD3 and CHD4 to form the nucleosome remodeling and histone deacetylation (NuRD) complex , or with SIN3 , SAP18 and SAP30 to form the SIN3 HDAC complex. Component of a BHC histone deacetylase complex that contains HDAC1 , HDAC2 , HMG20B/BRAF35 , AOF2/LSD1 , RCOR1/CoREST and PHF21A/BHC80. The BHC complex may also contain ZMYM2 , ZNF217 , ZMYM3 , GSE1 and GTF2I. Part of a complex containing the core histones H2A , H2B , H3 and H4 , DEK and unphosphorylated DAXX. Part of a complex containing ATR and CHD4. Forms a heterologous complex at least with YY1. Interacts with ATR , DNMT1 , MINT , HDAC7 , HDAC10 , HCFC1 , NRIP1 , MJD2A/JHDM3A , PRDM6 , SAP30 , SETDB1 and SUV39H1. Interacts with the non-histone region of H2AFY. Interacts with PELP1. Component of a mSin3A corepressor complex that contains SIN3A , SAP130 , SUDS3/SAP45 , ARID4B/SAP180 , HDAC1 and HDAC2. Interacts with CBFA2T3. Interacts with SAP30L. ,tissue specificity:Widely expressed; lower levels in brain and lung. ,

negative regulation of transcription from RNA polymerase II promoter , chromatin organization , chromatin remodeling ,chromatin silencing , maintenance of chromatin silencing , transcription , regulation of transcription , DNA-dependent ,regulation of transcription from RNA polymerase II promoter , protein amino acid deacetylation , positive regulation of cell proliferation , response to temperature stimulus , response to heat , response to abiotic stimulus , negative regulation of biosynthetic process , positive regulation of biosynthetic process , response to organic substance ,regulation of specific transcription from RNA polymerase II promoter , positive regulation of specific transcription from RNA polymerase II promoter , negative regulation of specific transcription from RNA polymerase II promoter , positive regulation of macromolecule biosynthetic process , negative regulation of macromolecule biosynthetic process , positive regulation of macromolecule metabolic process , negative regulation of macromolecule metabolic process , positive regulation of gene expression , negative regulation of gene expression , regulation of collagen metabolic process ,positive regulation of collagen metabolic process , regulation of receptor biosynthetic process , positive regulation of receptor biosynthetic process , response to organic cyclic substance , response to tropane , gene silencing , negative regulation of transcription , chromatin modification , covalent chromatin modification , histone modification , histone deacetylation , regulation of proteolysis , negative regulation of cellular biosynthetic process , positive regulation of cellular biosynthetic process , regulation of cellular protein metabolic process , positive regulation of cellular protein metabolic process , negative regulation of gene-specific transcription , regulation of gene-specific transcription ,regulation of collagen biosynthetic process , positive regulation of collagen biosynthetic process , cellular response to stress , cellular response to heat , regulation of gene expression , epigenetic , regulation of cell proliferation , response to cocaine , response to drug , positive regulation of gene-specific transcription , response to alkaloid , negative regulation of DNA binding , negative regulation of transcription factor activity , negative regulation of molecular function ,regulation of multicellular organismal metabolic process , positive regulation of multicellular organismal metabolic process , regulation of MHC class II biosynthetic process , negative regulation of MHC class II biosynthetic process ,regulation of transcription , negative regulation of cell cycle , negative regulation of gene expression , epigenetic ,positive regulation of proteolysis , negative regulation of transcription , DNA-dependent , positive regulation of transcription , DNA-dependent , negative regulation of nucleobase , nucleoside , nucleotide and nucleic acid metabolic process , positive regulation of nucleobase , nucleoside , nucleotide and nucleic acid metabolic process , positive regulation of transcription , positive regulation of transcription from RNA polymerase II promoter , regulation of transcription factor activity , regulation of binding , negative regulation of binding , regulation of DNA binding , negative regulation of nitrogen compound metabolic process , positive regulation of nitrogen compound metabolic process ,positive regulation of multicellular organismal process , positive regulation of protein metabolic process , regulation of RNA metabolic process , negative regulation of RNA metabolic process , positive regulation of RNA metabolic process ,chromosome organization , regulation of cell cycle ,

Nucleus . Cytoplasm .