GSK3B

GSK3B ;
Glycogen synthase kinase-3 beta ;
GSK-3 beta ;
Serine/threonine-protein kinase GSK3B

catalytic activity:ATP + [tau protein] = ADP + [tau protein] phosphate. ,enzyme regulation:Inhibited when phosphorylated by AKT1. ,function:Participates in the Wnt signaling pathway. Implicated in the hormonal control of several regulatory proteins including glycogen synthase , MYB and the transcription factor JUN. Phosphorylates JUN at sites proximal to its DNA-binding domain , thereby reducing its affinity for DNA. Phosphorylates MUC1 in breast cancer cells , and decreases the interaction of MUC1 with CTNNB1/beta-catenin. ,PTM:Phosphorylated by AKT1 and ILK1. ,similarity:Belongs to the protein kinase superfamily. ,similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily. ,similarity:Contains 1 protein kinase domain. ,subunit:Monomer (By similarity) . Interacts with CABYR , MUC1 , NIN and PRUNE. ,tissue specificity:Expressed in testis , thymus , prostate and ovary and weakly expressed in lung , brain and kidney. ,

re-entry into mitotic cell cycle , polysaccharide metabolic process , glycogen metabolic process , monosaccharide metabolic process , glucose metabolic process , cellular glucan metabolic process , generation of precursor metabolites and energy , energy reserve metabolic process , protein amino acid phosphorylation , protein targeting , protein export from nucleus , phosphorus metabolic process , phosphate metabolic process , intracellular protein transport ,nucleocytoplasmic transport , anti-apoptosis , ER overload response , ER-nuclear signaling pathway , cell cycle , cell surface receptor linked signal transduction , intracellular signaling cascade , protein localization , regulation of cell death ,protein transport , energy derivation by oxidation of organic compounds , Wnt receptor signaling pathway ,phosphorylation , peptidyl-serine phosphorylation , peptidyl-serine modification , hexose metabolic process , cell cycle process , positive regulation of protein complex assembly , regulation of intracellular transport , positive regulation of intracellular transport , regulation of protein localization , regulation of intracellular protein transport , cellular response to stress , cellular protein localization , response to endoplasmic reticulum stress , regulation of apoptosis , negative regulation of apoptosis , regulation of programmed cell death , negative regulation of programmed cell death ,regulation of protein complex assembly , glucan metabolic process , regulation of cellular component biogenesis , cellular polysaccharide metabolic process , establishment of protein localization , fat cell differentiation , regulation of nucleocytoplasmic transport , positive regulation of nucleocytoplasmic transport , regulation of protein export from nucleus , positive regulation of protein export from nucleus , intracellular transport , positive regulation of transport ,positive regulation of cellular component organization , nuclear export , nuclear transport , positive regulation of protein transport , regulation of protein transport , Wnt receptor signaling pathway through beta-catenin , regulation of cellular localization , negative regulation of cell death , regulation of establishment of protein localization , cellular macromolecule localization ,

Cytoplasm . Nucleus . Cell membrane . The phosphorylated form shows localization to cytoplasm and cell membrane (PubMed:20937854) . The MEMO1-RHOA-DIAPH1 signaling pathway controls localization of the phosphorylated form to the cell membrane (PubMed:20937854) . .