详细信息
推荐稀释比
Reconstitute in sterile water for a stock solution
组成
Supplied as solution form in PBS pH 7.5./ Lyophilized from PBS pH 7.5.
来源
Mammalian cells
纯度
>90% as determined by SDS-PAGE
储存
Use a manual defrost freezer and avoid repeated freeze thaw cycles.
Store at 2 to 8 °C for one week .
Store at -20 to -80 °C for twelve months from the date of receipt.
抗原&靶点信息
序列:
A DNA sequence encoding the human EGFR(Met1-Ser645) was fused with the C-terminal His tag
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别名:
EGFR ;
ERBB ;
ERBB1 ;
HER1 ;
Epidermal growth factor receptor ;
Proto-oncogene c-ErbB-1 ;
Receptor tyrosine-protein kinase erbB-1
ERBB ;
ERBB1 ;
HER1 ;
Epidermal growth factor receptor ;
Proto-oncogene c-ErbB-1 ;
Receptor tyrosine-protein kinase erbB-1
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细胞定位:
Cell membrane ; Single-pass type I membrane protein . Endoplasmic reticulum membrane ; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Nucleus membrane; Single-pass type I membrane protein. Endosome . Endosome membrane. Nucleus . In response to EGF, translocated from the cell membrane to the nucleus via Golgi and ER (PubMed:20674546, PubMed:17909029). Endocytosed upon activation by ligand (PubMed:2790960, PubMed:17182860, PubMed:27153536, PubMed:17909029). Colocalized with GPER1 in the nucleus of estrogen agonist-induced cancer-associated fibroblasts (CAF) (PubMed:20551055). .; [Isoform 2]: Secreted.
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组织表达:
Ubiquitously expressed. Isoform 2 is also expressed in ovarian cancers.
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信号通路
Cellular Processes >> Cellular community - eukaryotes >> Focal adhesion
Cellular Processes >> Cellular community - eukaryotes >> Adherens junction
Cellular Processes >> Cellular community - eukaryotes >> Gap junction
Cellular Processes >> Cell motility >> Regulation of actin cytoskeleton
Organismal Systems >> Endocrine system >> GnRH signaling pathway
Organismal Systems >> Endocrine system >> Estrogen signaling pathway
Organismal Systems >> Endocrine system >> Oxytocin signaling pathway
Organismal Systems >> Endocrine system >> Relaxin signaling pathway
Human Diseases >> Cancer: overview >> Pathways in cancer
Human Diseases >> Cancer: overview >> MicroRNAs in cancer
Human Diseases >> Cancer: overview >> Central carbon metabolism in cancer
Human Diseases >> Cancer: overview >> PD-L1 expression and PD-1 checkpoint pathway in cancer
Human Diseases >> Cancer: specific types >> Colorectal cancer
Human Diseases >> Cancer: specific types >> Pancreatic cancer
Human Diseases >> Cancer: specific types >> Hepatocellular carcinoma
Human Diseases >> Cancer: specific types >> Gastric cancer
Human Diseases >> Cancer: specific types >> Glioma
Human Diseases >> Cancer: specific types >> Melanoma
Human Diseases >> Cancer: specific types >> Bladder cancer
Human Diseases >> Cancer: specific types >> Prostate cancer
Human Diseases >> Cancer: specific types >> Endometrial cancer
Human Diseases >> Cancer: specific types >> Breast cancer
Human Diseases >> Cancer: specific types >> Non-small cell lung cancer
Environmental Information Processing >> Signal transduction >> MAPK signaling pathway
Environmental Information Processing >> Signal transduction >> ErbB signaling pathway
Environmental Information Processing >> Signal transduction >> Ras signaling pathway
Environmental Information Processing >> Signal transduction >> Rap1 signaling pathway
Environmental Information Processing >> Signal transduction >> JAK-STAT signaling pathway
Environmental Information Processing >> Signal transduction >> HIF-1 signaling pathway
Environmental Information Processing >> Signal transduction >> FoxO signaling pathway
Environmental Information Processing >> Signal transduction >> Calcium signaling pathway
Environmental Information Processing >> Signal transduction >> Phospholipase D signaling pathway
Environmental Information Processing >> Signal transduction >> PI3K-Akt signaling pathway
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