NOS3

Nitric oxide synthase,endothelial ;
Constitutive NOS ;
cNOS ;
EC-NOS ;
Endothelial NOS ;
eNOS ;
NOS type III ;
NOSIII ;

catalytic activity:L-arginine + n NADPH + n H (+) + m O (2) = citrulline + nitric oxide + n NADP (+) . ,cofactor:Binds 1 FAD. ,cofactor:Binds 1 FMN. ,cofactor:Heme group. ,cofactor:Tetrahydrobiopterin (BH4) . May stabilize the dimeric form of the enzyme. ,enzyme regulation:Stimulated by calcium/calmodulin. Inhibited by NOSIP and NOSTRIN. ,function:Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF) -induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets. ,online information:Nitric oxide synthase entry ,polymorphism:Variation in NOS3 seem to be associated with susceptibility to coronary spasm. ,similarity:Belongs to the NOS family. ,similarity:Contains 1 FAD-binding FR-type domain. ,similarity:Contains 1 flavodoxin-like domain. ,subcellular location:Specifically associates with actin cytoskeleton in the G2 phase of the cell cycle; which is favored by interaction with NOSIP and results in a reduced enzymatic activity. ,subunit:Homodimer. Interacts with NOSIP and NOSTRIN. ,tissue specificity:Platelets , placenta , liver and kidney. ,

response to acid , angiogenesis , ovulation from ovarian follicle , blood vessel development , response to hypoxia ,vasculature development , blood vessel remodeling , regulation of systemic arterial blood pressure by hormone ,regulation of sodium ion transport , response to molecule of bacterial origin , reproductive developmental process ,muscle system process , circulatory system process , vascular process in circulatory system , regulation of systemic arterial blood pressure mediated by a chemical signal , regulation of systemic arterial blood pressure , regulation of systemic arterial blood pressure by endothelin , regulation of nucleotide metabolic process , arginine metabolic process ,arginine catabolic process , nitric oxide biosynthetic process , anti-apoptosis , cell motion , mitochondrion organization ,cell surface receptor linked signal transduction , gamete generation , female gamete generation , sex differentiation ,aging , blood circulation , regulation of blood pressure , negative regulation of cell proliferation , gonad development ,female gonad development , cellular amino acid catabolic process , glutamine family amino acid metabolic process ,glutamine family amino acid catabolic process , response to temperature stimulus , amine catabolic process , response to heat , response to bacterium , response to abiotic stimulus , response to endogenous stimulus , response to hormone stimulus , response to organic substance , response to inorganic substance , response to metal ion , response to organic nitrogen , response to lead ion , regulation of platelet activation , negative regulation of platelet activation ,regulation of cell death , regulation of metal ion transport , response to organic cyclic substance , response to amine stimulus , regulation of muscle hyperplasia , negative regulation of muscle hyperplasia , negative regulation of muscle adaptation , smooth muscle adaptation , smooth muscle hyperplasia , organic acid catabolic process , cell migration ,sexual reproduction , ovulation cycle process , regulation of blood coagulation , negative regulation of blood coagulation , respiratory tube development , lung development , ovulation , regulation of cyclic nucleotide metabolic process , regulation of cyclic nucleotide biosynthetic process , regulation of nucleotide biosynthetic process , regulation of cGMP metabolic process , regulation of cGMP biosynthetic process , regulation of cyclase activity , positive regulation of cyclase activity , regulation of guanylate cyclase activity , positive regulation of guanylate cyclase activity ,lipopolysaccharide-mediated signaling pathway , regulation of response to external stimulus , response to estradiol stimulus , response to lipopolysaccharide , multicellular organism reproduction , response to cytokine stimulus , response to fluid shear stress , regulation of tube size , tube development , regulation of cell proliferation , regulation of vasodilation , response to drug , ovulation cycle , regulation of apoptosis , negative regulation of apoptosis , regulation of programmed cell death , negative regulation of programmed cell death , positive regulation of catalytic activity , negative regulation of catalytic activity , response to amino acid stimulus , regulation of potassium ion transport , negative regulation of potassium ion transport , regulation of ion transport , negative regulation of ion transport , response to peptide hormone stimulus , muscle adaptation , regulation of muscle adaptation , endothelial cell migration , response to estrogen stimulus , regulation of system process , negative regulation of molecular function , positive regulation of molecular function , nitrogen compound biosynthetic process , development of primary sexual characteristics , response to ethanol , regulation of angiogenesis , positive regulation of angiogenesis , positive regulation of vasodilation , nitric oxide metabolic process , carboxylic acid catabolic process , development of primary female sexual characteristics ,female sex differentiation , rhythmic process , blood vessel morphogenesis , response to steroid hormone stimulus ,reproductive structure development , reproductive process in a multicellular organism , regulation of smooth muscle cell proliferation , negative regulation of smooth muscle cell proliferation , tissue remodeling , cell motility , regulation of coagulation , negative regulation of coagulation , regulation of cell activation , negative regulation of cell activation ,regulation of blood vessel size , endocrine process , negative regulation of transport , positive regulation of developmental process , positive regulation of multicellular organismal process , negative regulation of multicellular organismal process , regulation of hydrolase activity , regulation of lyase activity , negative regulation of hydrolase activity , positive regulation of lyase activity , localization of cell , regulation of calcium ion transport , negative regulation of calcium ion transport , response to hyperoxia , response to lipoprotein stimulus , oxidation reduction , respiratory system development , negative regulation of cell death , response to oxygen levels ,

Cell membrane. Membrane , caveola. Cytoplasm , cytoskeleton. Golgi apparatus. Specifically associates with actin cytoskeleton in the G2 phase of the cell cycle; which is favored by interaction with NOSIP and results in a reduced enzymatic activity.