p56 Dok-2 (Phospho Tyr299) Cell-Based Colorimetric ELISA Kit
-KA1560C
主要信息
Reactivity
Human, Mouse
Applications
ELISA
Conjugate/Modification
Phospho
详细信息
储存
2-8°C/6 months,Ship by ice bag
修饰
Phospho
检测方法
Colorimetric
相关产品
Primary Antibodies
Dok-2 Rabbit pAb
YT1396
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Primary Antibodies
Dok-2 (Phospho Tyr345) Rabbit pAb
YP1115
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Primary Antibodies
Dok-2 (Phospho Tyr299) Rabbit pAb
YP0085
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ELISA Kits
Total p56 Dok-2 Cell-Based Colorimetric ELISA Kit
KA4211C
预览→
ELISA Kits
p56 Dok-2 (Phospho Tyr299) Cell-Based Colorimetric ELISA Kit
KA1560C
预览→
抗原&靶点信息
基因名称:
DOK2
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别名:
Docking protein 2 ;
Downstream of tyrosine kinase 2 ;
p56 ;
dok-2 ;
Downstream of tyrosine kinase 2 ;
p56 ;
dok-2 ;
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背景:
domain:PTB domain mediates receptor interaction. ,function:DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4 , as well as IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation. ,PTM:On immunoreceptor stimulation , phosphorylated on C-terminal tyrosine residues. Phosphorylation on Tyr-345 is required for binding to the SH2 domain of NCK. Phosphorylation on both Tyr-271 and Tyr-299 is required for interaction with RASGAP. ,similarity:Belongs to the DOK family. Type A subfamily. ,similarity:Contains 1 IRS-type PTB domain. ,similarity:Contains 1 PH domain. ,subunit:Interacts with phosphorylated RASGAP and EGFR. Interacts with RET and NCK. ,tissue specificity:Highly expressed in peripheral blood leukocytes , lymph nodes and spleen. Lower expression in thymus , bone marrow and fetal liver. ,
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功能:
cell surface receptor linked signal transduction , enzyme linked receptor protein signaling pathway , transmembrane receptor protein tyrosine kinase signaling pathway , intracellular signaling cascade , small GTPase mediated signal transduction , Ras protein signal transduction ,
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